Bioengineered vascular constructs as living models for in vitro cardiovascular research

Frederic Wolf, Felix Vogt, Thomas Schmitz-Rode, Stefan Jockenhoevel*, Petra Mela

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Cardiovascular diseases represent the most common cause of morbidity and mortality worldwide. In this review, we explore the potential of bioengineered vascular constructs as living models for in vitro cardiovascular research to advance the current knowledge of pathophysiological processes and support the development of clinical therapies. Bioengineered vascular constructs capable of recapitulating the cellular and mechanical environment of native vessels represent a valuable platform to study cellular interactions and signaling cascades, test drugs and medical devices under (patho)physiological conditions, with the additional potential benefit of reducing the number of animals required for preclinical testing.

Original languageEnglish
Pages (from-to)1446-1455
Number of pages10
JournalDrug Discovery Today
Volume21
Issue number9
DOIs
Publication statusPublished - Sep 2016

Keywords

  • SMOOTH-MUSCLE-CELLS
  • ADHESION MOLECULE EXPRESSION
  • FLUID SHEAR-STRESS
  • ENDOTHELIAL-CELLS
  • DISTURBED FLOW
  • TISSUE
  • STENT
  • COCULTURE
  • ATHEROSCLEROSIS
  • HEMODYNAMICS

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