Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity

Junmei Hu Frisk; Jo M Vanoevelen; Jorgen Bierau; Gunnar Pejler; Staffan Eriksson; Liya Wang

doi:10.1021/acsomega.1c05288

Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity

Junmei Hu Frisk, Jo M Vanoevelen, Jorgen Bierau, Gunnar Pejler, Staffan Eriksson, Liya Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Web of Science)

Original language	English
Pages (from-to)	33943-33952
Number of pages	10
Journal	Acs omega
Volume	6
Issue number	49
DOIs	https://doi.org/10.1021/acsomega.1c05288
Publication status	Published - 14 Dec 2021

Keywords

HUMAN THYMIDYLATE KINASE
THYMIDINE KINASE
CRYSTAL-STRUCTURES
MITOCHONDRIA
MECHANISM
GEOMETRY

Access to Document

10.1021/acsomega.1c05288

Cite this

@article{4685376535cd4709afc6584e8fe66efe,

title = "Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity",

keywords = "HUMAN THYMIDYLATE KINASE, THYMIDINE KINASE, CRYSTAL-STRUCTURES, MITOCHONDRIA, MECHANISM, GEOMETRY",

author = "Frisk, {Junmei Hu} and Vanoevelen, {Jo M} and Jorgen Bierau and Gunnar Pejler and Staffan Eriksson and Liya Wang",

year = "2021",

month = dec,

day = "14",

doi = "10.1021/acsomega.1c05288",

language = "English",

volume = "6",

pages = "33943--33952",

journal = "Acs omega",

issn = "2470-1343",

publisher = "American Chemical Society",

number = "49",

}

Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly : Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity. / Frisk, Junmei Hu; Vanoevelen, Jo M ; Bierau, Jorgen; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya.

In: Acs omega, Vol. 6, No. 49, 14.12.2021, p. 33943-33952.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly

T2 - Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity

AU - Frisk, Junmei Hu

AU - Vanoevelen, Jo M

AU - Bierau, Jorgen

AU - Pejler, Gunnar

AU - Eriksson, Staffan

AU - Wang, Liya

PY - 2021/12/14

Y1 - 2021/12/14

KW - HUMAN THYMIDYLATE KINASE

KW - THYMIDINE KINASE

KW - CRYSTAL-STRUCTURES

KW - MITOCHONDRIA

KW - MECHANISM

KW - GEOMETRY

U2 - 10.1021/acsomega.1c05288

DO - 10.1021/acsomega.1c05288

M3 - Article

C2 - 34926941

VL - 6

SP - 33943

EP - 33952

JO - Acs omega

JF - Acs omega

SN - 2470-1343

IS - 49

ER -