Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity

Junmei Hu Frisk, Jo M Vanoevelen, Jorgen Bierau, Gunnar Pejler, Staffan Eriksson, Liya Wang*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)
Original languageEnglish
Pages (from-to)33943-33952
Number of pages10
JournalAcs omega
Volume6
Issue number49
DOIs
Publication statusPublished - 14 Dec 2021

Keywords

  • HUMAN THYMIDYLATE KINASE
  • THYMIDINE KINASE
  • CRYSTAL-STRUCTURES
  • MITOCHONDRIA
  • MECHANISM
  • GEOMETRY

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