Bioartificial fabrication of regenerating blood vessel substitutes: requirements and current strategies

Mathias Wilhelmi, Stefan Jockenhoevel, Petra Mela*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Web of Science)

Abstract

This work reviews the tremendous development in the field of vascular graft tissue engineering driven by a clear and increasing clinical need for functional vascular replacements able to grow and remodel. The different strategies to tissue engineer blood vessels are presented, from the classical approach of a living implant generated in vitro by conditioning a cell-seeded scaffold to remarkable paradigm shifts either i) toward a completely biology-driven strategy (scaffold-free approaches) or ii) the opposite tendency of cell-free scaffolds aiming at eliciting the host reaction for in situ tissue engineering. In the scaffold-based approaches emphasis is given to the material choice.
Original languageEnglish
Pages (from-to)185-195
JournalBiomedizinische Technik
Volume59
Issue number3
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Keywords

  • bioartificial substitutes
  • biomaterials
  • blood vessels
  • scaffold
  • tissue engineering
  • vascular grafts

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