Bioactive Wound Dressing Gauze Loaded with Silver Nanoparticles Mediated by Acacia Gum

Mehrez El-Naggar*, Abdelrahman Abdelgawad*, Dalia Elsherbiny, Waffa El-shazly, Samaneh Ghazanfari, Mohamed Abdel-Aziz, Yasser Abd-Elmoneam

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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A wound dressing is very crucial component in wound healing process. Bioactive dressings play important role in wound sterilization and promote tissue healing and growth. The present work investigated the preparation of AgNPs in solid-state using acacia gum as both reductant and stabilizing agent. Sodium hydroxide (NaOH) was employed as activating agent and pH mediator. Acacia is a naturally occurring mixture of polysaccharides and glycoproteins. The obtained particles were in the range of 50 nm. The work was extended to evaluate the antimicrobial of AgNPs treated gauze cotton fabrics against gram positive (S. aureus), gram negative (P. aeruginosa) bacteria,C. albicans(yeast); andA. Niger(fungus). The inhibition zone of the as prepared silver nanoparticles was found to be 24 mm against both types of bacteria, 23 mm againstC. albicans(yeast), and inactive againstA. Niger(fungus). On the other hand, the treated gauze showed bactericidal behavior and a clear zone was found underneath the samples on the agar plate. The reduction percent in number of bacterial colonies of treated gauze fabrics in comparison to controlPseudomonas aeruginosaculture showed a reduction up to 100%. The aforementioned results promote the acquirement of bioactive antibacterial wound dressing.

Original languageEnglish
Pages (from-to)1349-1362
Number of pages14
JournalJournal of Cluster Science
Issue number6
Publication statusPublished - Nov 2020


  • Acacia gum
  • Silver nanoparticles
  • Solid state
  • Gauze fabric
  • Wound dressing


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