Bioactive tri-component nanofibers from cellulose acetate/lignin//N-vanillidene-phenylthiazole copper-(II) complex for potential diaper dermatitis control

Dalia A Elsherbiny, Abdelrahman M Abdelgawad, Mehrez E El-Naggar, Bahaa A Hemdan, Samaneh Ghazanfari, Stefan Jockenhövel, Orlando J Rojas

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Current research targets innovative medical textiles of nanofibrous nature and antibacterial activity to prevent diaper dermatitis. The work is based on electrospun nanofibers from cellulose acetate (CA) and lignin (Lig) polymers. A series of new copper complexes were synthesized and loaded to the CA/Lig solution mix then subjected to electrospinning, giving rise to the tricomponent bioactive mats CA/Lig/Cu-complex. The surface morphology of electrospun nanofiber mats was smooth and homogenous as the concentration of lignin increased in the mixture. The incorporation of lignin improved the electrospinnability of the cellulose acetate; however, it increased the fiber diameter. The water contact angle, absorption underload were significantly improved as lignin content increased. The incorporation of Cu-complex in electrospun CA and CA/Lig fiber mats occurred without any substantial change in the surface morphology, indicating well encapsulation of the complex. The electrospun mats were active against Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus epidermidis, and Streptococcus faecalis. The cytotoxicity, protein leakage, and biological results, together with the above studies, would advocate copper complex loaded CA/Lig nanofibers as a potential candidate for hygienic applications.

Original languageEnglish
Pages (from-to)703-718
Number of pages16
JournalInternational Journal of Biological Macromolecules
Volume205
Early online date4 Mar 2022
DOIs
Publication statusPublished - 30 Apr 2022

Keywords

  • ACETATE NANOFIBERS
  • ANTIBACTERIAL ACTIVITY
  • Antibacterial
  • COPPER(II)
  • Cellulose acetate
  • Diaper dermatitis
  • ELECTROSPUN NANOFIBERS
  • Electrospinning
  • FIBERS
  • Lignin
  • POLYMER NANOFIBERS
  • RELEASE
  • TECHNOLOGY

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