Bio-Based Covered Stents: The Potential of Biologically Derived Membranes

Shigeo Ichihashi, Alicia Fernandez-Colino, Frederic Wolf, Diana M. Rojas-Gonzalez, Kimihiko Kichikawa, Stefan Jockenhoevel, Thomas Schmitz-Rode, Petra Mela*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Endovascular treatment using bare metal stents or drug-eluting stents is routinely performed to restore the blood flow in the coronary and peripheral arteries; however, intimal hyperplasia and late stent thrombosis are still major issues leading to stent failure and often to the need for reintervention. Covered stents (CS) have emerged as an alternative approach to avoid intimal hyperplasia. They are characterized by the presence of a membrane that spans the struts of the stent and acts as a physical barrier to block the ingrowth of the neointimal tissue into the lumen. Currently used membrane materials include mainly synthetic polymers. Their main limitation is their lack of hemocompatibility, which can induce thrombosis and ultimately reocclusion, thus impairing the long-term performance of these devices. To overcome this issue, the use of biologically derived materials has been proposed with the aim of enhancing the biocompatibility and the capability of this type of stents to support endothelialization. The aim of this review is to give a comprehensive overview of the applications of bio-based CS as well as the different strategies followed for their development from the perspective of the material selection, fabrication approaches, and validation of the different concepts in animal and clinical trials. Impact Statement The use of bio-based materials (i.e., biologically derived materials that have either a biological origin, including engineered tissues, or a bio-inspired chemical composition) offers the potential to obtain covered stents (CS) with superior performance with respect to the currently available ones, which employ synthetic materials. This will advance and expand the clinical applicability of CS not only in the cardiovascular field but also for the treatment of other target areas such as segments of the respiratory, gastrointestinal, biliary, and urinary tracts.
Original languageEnglish
Pages (from-to)135-151
Number of pages17
JournalTissue Engineering - Part B: Reviews
Volume25
Issue number2
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • covered stents
  • bio-based materials
  • tissue engineering
  • SMALL-INTESTINAL SUBMUCOSA
  • BARE-METAL STENTS
  • DRUG-ELUTING STENT
  • ENGINEERED VASCULAR GRAFT
  • CORONARY-ARTERY-DISEASE
  • IN-VIVO EVALUATION
  • TISSUE ARCHITECTURE TECHNOLOGY
  • ELASTIN-LIKE RECOMBINAMERS
  • EXTRACELLULAR-MATRIX
  • BOVINE PERICARDIUM

Cite this

Ichihashi, S., Fernandez-Colino, A., Wolf, F., Rojas-Gonzalez, D. M., Kichikawa, K., Jockenhoevel, S., Schmitz-Rode, T., & Mela, P. (2019). Bio-Based Covered Stents: The Potential of Biologically Derived Membranes. Tissue Engineering - Part B: Reviews, 25(2), 135-151. https://doi.org/10.1089/ten.teb.2018.0207