@article{d94125a21efc49b7a94980e15f6daefa,
title = "Bile acids drive the newborn's gut microbiota maturation",
abstract = "Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense and highly dynamic intestinal microbiota. Whereas the effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, the liver undergoes functional transition from a hematopoietic organ to a central organ of metabolic regulation and immune surveillance. The aim of the present study was to analyze the influence of the developing hepatic function and liver metabolism on the early intestinal microbiota. Here, we report on the characterization of the colonization dynamics and liver metabolism in the murine gastrointestinal tract (n = 6-10 per age group) using metabolomic and microbial profiling in combination with multivariate analysis. We observed major agedependent microbial and metabolic changes and identified bile acids as potent drivers of the early intestinal microbiota maturation. Consistently, oral administration of tauro-cholic acid or beta-tauro-murocholic acid to newborn mice (n = 7 -14 per group) accelerated postnatal microbiota maturation.",
keywords = "INTESTINAL MICROBIOTA, DIVERSITY, BACTERIAL, WINDOW",
author = "{van Best}, N. and U. Rolle-Kampczyk and Schaap, {F. G.} and M. Basic and Damink, {S. W. M. Olde} and A. Bleich and Savelkoul, {P. H. M.} and {von Bergen}, M. and J. Penders and Hornef, {M. W.}",
note = "Funding Information: We would like to thank Xinwei Chang and Martina Bernecker for excellent technical support. This work was supportesd by the priority program SPP1656 (HO2236/9-2 to M.W.H. and BL953/5-2 to A.B. and M.B.), the Collaborative Research Centers CRC1371 (Project-ID 395357507-SFB1371 to A.B. and M.B.) and CRC1382 (Project-ID 403224013 —SFB 1382 to M.W.H. and M.v.B.) and the individual grants HO2236/14-1 and HO2236/17-1 (to M.W.H.) from the German Research Foundation (DFG), a grant from the Interdisciplinary Center for Clinical Research (IZKF) within the faculty of Medicine at the RWTH Aachen University (to M.W.H.), as well as a D2 seeding grant from the School of Nutrition and Translational Research in Metabolism (NUTRIM) of Maastricht University (to N.v.B.). Funding Information: All data from this study are publicly available. V4 16S rDNA bacterial sequences have been submitted to the Qiita (https://qiita.ucsd.edu/study/description/10719) and ENA (https://www.ebi.ac.uk/ena/data/view/PRJEB33959) databases under accession No. 10719 and ERP116798, respectively. The metbolomic data are available at the NIH Common Fund{\textquoteright}s National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org/data/DRCCMetadata.php? Mode=Project&ProjectID=PR000952) where it has been assigned the Study ID ST001388, ST001389, ST001396, ST001397 and the Project ID (PR000952). The data can be accessed directly via it{\textquoteright}s Project https://doi.org/10.21228/M8N397. This work is supported by NIH grant U2C-DK119886. Source data are provided with this paper. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = jul,
day = "23",
doi = "10.1038/s41467-020-17183-8",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}