Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice

Otto T. Mykkanen*, Giedrius Kalesnykas, Michiel Adriaens, Chris T. Evelo, Riitta Torronen, Kai Kaarniranta

*Corresponding author for this work

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Obesity- and diabetes-associated visual impairment and vascular dysfunctions are increasing as causes of vision loss. The detailed mechanisms of how obesity and diabetes affect eye health are still largely unknown, but animal models have been useful in exploring the effects of potential protective compounds, i.e., compounds characterized by antioxidant and anti-inflammatory properties. These properties occur in anthocyanins, and bilberries (European wild blueberries, Vaccinium myrtillus) are a major source of dietary anthocyanins in Nordic diets. The main aim of the present work was to study the protective effects of dietary bilberries (BB) on the level of gene expression in retinas in mice that develop obesity when fed a high-fat diet (HFD).
Original languageEnglish
Pages (from-to)2338-2351
Number of pages14
JournalMolecular Vision
Issue number247
Publication statusPublished - 7 Sep 2012

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