Bilateral Orbitofrontal Repetitive Transcranial Magnetic Stimulation in Frontal Lobe Epilepsy: A Case Report

G. Mikellides*, P. Michael, A. Gregoriou, T. Schuhmann, A.T. Sack

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Epilepsy is a common and severe neurological disorder affecting millions of people worldwide. Nowadays, antiseizure medications (ASMs) are the main treatment for most epilepsy patients, although many of them do not respond to ASMs and suffer from drug-resistant epilepsy (DRE). Alternative and novel treatment methods have been offered nowadays, showing promising results for the treatment of DRE. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method that has become increasingly popular in the last decades. This article reports a patient with frontal lobe epilepsy. We aimed to investigate whether bilateral orbitofrontal (OFC) low-frequency rTMS (LF-rTMS) is feasible and tolerable, safe, and potentially clinically effective in treating epileptic seizures. The patient’s satisfaction with rTMS therapy was self-reported to be high, as rTMS helped in reducing the frequency of the focal attacks and completely abolished the preceding feeling of fear and panic. Therefore, bilateral OFC rTMS treatment can be well tolerated in patients with frontal epilepsy although the findings of the present case report with regard to clinical efficacy warrant further investigation.
Original languageEnglish
Pages (from-to)729-737
Number of pages9
JournalCase Reports in Neurology
Issue number3
Early online date16 Nov 2021
Publication statusPublished - 2021


  • Drug-resistant epilepsy
  • Epilepsy
  • Orbitofrontal cortex
  • RTMS
  • Repetitive transcranial magnetic stimulation
  • TMS

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