Bi-ventricular pacing improves pump function only with adequate myocardial perfusion in canine hearts with pseudo-left bundle branch block

Mark Svendsen, Frits W. Prinzen, Mithilesh K. Das, Zachary Berwick, Matthew Rybka, Johnathan D. Tune, William Combs, Edward J. Berbari, Ghassan S. Kassab*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)


Bi-ventricular (BiV) pacing is an effective therapy for the treatment of cardiac electromechanical (EM) dysfunction. The reason(s), however, for therapy non-response in approximately one-third of the subjects remains unclear, especially as it relates to myocardial perfusion and pacing location. In this study, we examined how acute BiV pacing response may be related to underlying myocardial perfusion coupled with pacing near or distant to the area of perfusion. In 10 open-chest anesthetized canines, coronary blood flow to the left ventricular (LV) anterior wall (AW: n = 5) and lateral wall (LW: n = 5) was controlled during four pacing conditions: right atrial, right ventricular (pseudo-left bundle branch block; [pseudo-LBBB]), BiV-LW and BiV-AW. Local EM function (piezo-electrical crystals and electrodes), along with global hemodynamic parameters, were measured during all pacing conditions at three coronary perfusion rates (>= 0.40 mL/min/g, 0.20-0.40 mL/min/g and
Original languageEnglish
Pages (from-to)644-651
JournalExperimental Biology and Medicine
Issue number6
Publication statusPublished - Jun 2012


  • BiV pacing
  • myocardial perfusion
  • hemodynamics
  • ischemia
  • mechanics

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