Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

B.D. Zlatopolskiy; R. Kandler; D. Kobus; F.M. Mottaghy; B. Neumaier

doi:10.1039/c2cc31335a

Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

B.D. Zlatopolskiy
, R. Kandler
, D. Kobus
, F.M. Mottaghy
, B. Neumaier^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.

Original language	English
Pages (from-to)	7134-7136
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	57
DOIs	https://doi.org/10.1039/c2cc31335a
Publication status	Published - 1 Jan 2012

Keywords

F-18
PET

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10.1039/c2cc31335a

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title = "Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions",

abstract = "Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.",

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author = "B.D. Zlatopolskiy and R. Kandler and D. Kobus and F.M. Mottaghy and B. Neumaier",

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T1 - Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

AU - Zlatopolskiy, B.D.

AU - Kandler, R.

AU - Kobus, D.

AU - Mottaghy, F.M.

AU - Neumaier, B.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.

AB - Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.

KW - F-18

KW - PET

U2 - 10.1039/c2cc31335a

DO - 10.1039/c2cc31335a

M3 - Article

SN - 1359-7345

VL - 48

SP - 7134

EP - 7136

JO - Chemical Communications

JF - Chemical Communications

IS - 57

ER -

Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

Abstract

Keywords

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