Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

B.D. Zlatopolskiy; R. Kandler; D. Kobus; F.M. Mottaghy; B. Neumaier

doi:10.1039/c2cc31335a

Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

B.D. Zlatopolskiy, R. Kandler, D. Kobus, F.M. Mottaghy, B. Neumaier^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.

Original language	English
Pages (from-to)	7134-7136
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	57
DOIs	https://doi.org/10.1039/c2cc31335a
Publication status	Published - 1 Jan 2012

Keywords

F-18
PET

Access to Document

10.1039/c2cc31335a

Cite this

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abstract = "Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.",

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AU - Mottaghy, F.M.

AU - Neumaier, B.

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AB - Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.

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DO - 10.1039/c2cc31335a

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