Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions

B.D. Zlatopolskiy, R. Kandler, D. Kobus, F.M. Mottaghy, B. Neumaier*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.
Original languageEnglish
Pages (from-to)7134-7136
Number of pages3
JournalChemical Communications
Issue number57
Publication statusPublished - 1 Jan 2012


  • F-18
  • PET

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