TY - JOUR
T1 - Between-site reliability of startle prepulse inhibition across two early psychosis consortia
AU - Cadenhead, Kristin S.
AU - Addington, Jean
AU - Cannon, Tyrone D.
AU - Cornblatt, Barbara A.
AU - de la Fuente-Sandoval, Camilo
AU - Mathalon, Dan H.
AU - Perkins, Diana O.
AU - Seidman, Larry J.
AU - Tsuang, Ming
AU - Walker, Elaine F.
AU - Woods, Scott W.
AU - Bachman, Peter
AU - Belger, Ayse
AU - Carrion, Ricardo E.
AU - Donkers, Franc C. L.
AU - Duncan, Erica
AU - Johannesen, Jason
AU - Leon-Ortiz, Pablo
AU - Light, Gregory
AU - Mondragon, Alejandra
AU - Niznikiewicz, Margaret
AU - Nunag, Jason
AU - Roach, Brian J.
AU - Solis-Vivanco, Rodolfo
PY - 2013/8/7
Y1 - 2013/8/7
N2 - Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; however, between-site stability has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling participants studies were carried out as a part of quality assurance procedures to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) consortium, eight normal participants traveled to each of the eight NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy participants were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between-site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites.
AB - Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; however, between-site stability has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling participants studies were carried out as a part of quality assurance procedures to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) consortium, eight normal participants traveled to each of the eight NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy participants were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between-site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multisite studies, it is essential to institute quality assurance procedures early and establish between-site reliability to assure comparable data across sites.
KW - endophenotype
KW - prepulse inhibition
KW - reliability
KW - startle
U2 - 10.1097/WNR.0b013e3283637845
DO - 10.1097/WNR.0b013e3283637845
M3 - Article
C2 - 23799460
SN - 0959-4965
VL - 24
SP - 626
EP - 630
JO - Neuroreport
JF - Neuroreport
IS - 11
ER -