Better survival of renal cell carcinoma in patients with inflammatory bowel disease

L.A. Derikx, L.H. Nissen, J.P. Drenth, C.M. van Herpen, W. Kievit, R.H. Verhoeven, P.F. Mulders, C.A. Hulsbergen van Kaa, M.J. Boers-Sonderen, T.R. van den Heuvel, Marieke J. Pierik, I.D. Nagtegaal, F. Hoentjen

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

BACKGROUND: Immunosuppressive therapy may impact cancer risk in inflammatory bowel disease (IBD). Cancer specific data regarding risk and outcome are scarce and data for renal cell carcinoma (RCC) are lacking. We aimed(1) to identify risk factors for RCC development in IBD patients (2) to compare RCC characteristics, outcome and survival between IBD patients and the general population. METHODS: A PALGA (Dutch Pathology Registry) search was performed to establish a case group consisting of all IBD patients with incident RCC in The Netherlands (1991-2013). Cases were compared with two separate control groups: (A) with a population-based IBD cohort for identification of risk factors (B) with a RCC cohort from the general population to compare RCC characteristics and outcomes. RESULTS: 180 IBD patients with RCC were identified. Pancolitis (OR 1.8-2.5), penetrating Crohn's disease (OR 2.8), IBD related surgery (OR 3.7-4.5), male gender (OR 3.2-5.0) and older age at IBD onset (OR 1.0-1.1) were identified as independent risk factors for RCC development. IBD patients had a significantly lower age at RCC diagnosis (p < 0.001), lower N-stage (p = 0.025), lower M-stage (p = 0.020) and underwent more frequently surgical treatment for RCC (p < 0.001) compared to the general population. This translated into a better survival (p = 0.026; HR 0.7) independent of immunosuppression. CONCLUSIONS: IBD patients with a complex phenotype are at increased risk to develop RCC. They are diagnosed with RCC at a younger age and at an earlier disease stage compared to the general population. This translates into a better survival independent of immunosuppressive or anti-TNFalpha therapy.
Original languageEnglish
JournalOncotarget
DOIs
Publication statusPublished - 1 Jan 2015

Cite this

Derikx, L. A., Nissen, L. H., Drenth, J. P., van Herpen, C. M., Kievit, W., Verhoeven, R. H., ... Hoentjen, F. (2015). Better survival of renal cell carcinoma in patients with inflammatory bowel disease. Oncotarget. https://doi.org/10.18632/oncotarget.5186
Derikx, L.A. ; Nissen, L.H. ; Drenth, J.P. ; van Herpen, C.M. ; Kievit, W. ; Verhoeven, R.H. ; Mulders, P.F. ; Hulsbergen van Kaa, C.A. ; Boers-Sonderen, M.J. ; van den Heuvel, T.R. ; Pierik, Marieke J. ; Nagtegaal, I.D. ; Hoentjen, F. / Better survival of renal cell carcinoma in patients with inflammatory bowel disease. In: Oncotarget. 2015.
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title = "Better survival of renal cell carcinoma in patients with inflammatory bowel disease",
abstract = "BACKGROUND: Immunosuppressive therapy may impact cancer risk in inflammatory bowel disease (IBD). Cancer specific data regarding risk and outcome are scarce and data for renal cell carcinoma (RCC) are lacking. We aimed(1) to identify risk factors for RCC development in IBD patients (2) to compare RCC characteristics, outcome and survival between IBD patients and the general population. METHODS: A PALGA (Dutch Pathology Registry) search was performed to establish a case group consisting of all IBD patients with incident RCC in The Netherlands (1991-2013). Cases were compared with two separate control groups: (A) with a population-based IBD cohort for identification of risk factors (B) with a RCC cohort from the general population to compare RCC characteristics and outcomes. RESULTS: 180 IBD patients with RCC were identified. Pancolitis (OR 1.8-2.5), penetrating Crohn's disease (OR 2.8), IBD related surgery (OR 3.7-4.5), male gender (OR 3.2-5.0) and older age at IBD onset (OR 1.0-1.1) were identified as independent risk factors for RCC development. IBD patients had a significantly lower age at RCC diagnosis (p < 0.001), lower N-stage (p = 0.025), lower M-stage (p = 0.020) and underwent more frequently surgical treatment for RCC (p < 0.001) compared to the general population. This translated into a better survival (p = 0.026; HR 0.7) independent of immunosuppression. CONCLUSIONS: IBD patients with a complex phenotype are at increased risk to develop RCC. They are diagnosed with RCC at a younger age and at an earlier disease stage compared to the general population. This translates into a better survival independent of immunosuppressive or anti-TNFalpha therapy.",
author = "L.A. Derikx and L.H. Nissen and J.P. Drenth and {van Herpen}, C.M. and W. Kievit and R.H. Verhoeven and P.F. Mulders and {Hulsbergen van Kaa}, C.A. and M.J. Boers-Sonderen and {van den Heuvel}, T.R. and Pierik, {Marieke J.} and I.D. Nagtegaal and F. Hoentjen",
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Derikx, LA, Nissen, LH, Drenth, JP, van Herpen, CM, Kievit, W, Verhoeven, RH, Mulders, PF, Hulsbergen van Kaa, CA, Boers-Sonderen, MJ, van den Heuvel, TR, Pierik, MJ, Nagtegaal, ID & Hoentjen, F 2015, 'Better survival of renal cell carcinoma in patients with inflammatory bowel disease', Oncotarget. https://doi.org/10.18632/oncotarget.5186

Better survival of renal cell carcinoma in patients with inflammatory bowel disease. / Derikx, L.A.; Nissen, L.H.; Drenth, J.P.; van Herpen, C.M.; Kievit, W.; Verhoeven, R.H.; Mulders, P.F.; Hulsbergen van Kaa, C.A.; Boers-Sonderen, M.J.; van den Heuvel, T.R.; Pierik, Marieke J.; Nagtegaal, I.D.; Hoentjen, F.

In: Oncotarget, 01.01.2015.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Better survival of renal cell carcinoma in patients with inflammatory bowel disease

AU - Derikx, L.A.

AU - Nissen, L.H.

AU - Drenth, J.P.

AU - van Herpen, C.M.

AU - Kievit, W.

AU - Verhoeven, R.H.

AU - Mulders, P.F.

AU - Hulsbergen van Kaa, C.A.

AU - Boers-Sonderen, M.J.

AU - van den Heuvel, T.R.

AU - Pierik, Marieke J.

AU - Nagtegaal, I.D.

AU - Hoentjen, F.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - BACKGROUND: Immunosuppressive therapy may impact cancer risk in inflammatory bowel disease (IBD). Cancer specific data regarding risk and outcome are scarce and data for renal cell carcinoma (RCC) are lacking. We aimed(1) to identify risk factors for RCC development in IBD patients (2) to compare RCC characteristics, outcome and survival between IBD patients and the general population. METHODS: A PALGA (Dutch Pathology Registry) search was performed to establish a case group consisting of all IBD patients with incident RCC in The Netherlands (1991-2013). Cases were compared with two separate control groups: (A) with a population-based IBD cohort for identification of risk factors (B) with a RCC cohort from the general population to compare RCC characteristics and outcomes. RESULTS: 180 IBD patients with RCC were identified. Pancolitis (OR 1.8-2.5), penetrating Crohn's disease (OR 2.8), IBD related surgery (OR 3.7-4.5), male gender (OR 3.2-5.0) and older age at IBD onset (OR 1.0-1.1) were identified as independent risk factors for RCC development. IBD patients had a significantly lower age at RCC diagnosis (p < 0.001), lower N-stage (p = 0.025), lower M-stage (p = 0.020) and underwent more frequently surgical treatment for RCC (p < 0.001) compared to the general population. This translated into a better survival (p = 0.026; HR 0.7) independent of immunosuppression. CONCLUSIONS: IBD patients with a complex phenotype are at increased risk to develop RCC. They are diagnosed with RCC at a younger age and at an earlier disease stage compared to the general population. This translates into a better survival independent of immunosuppressive or anti-TNFalpha therapy.

AB - BACKGROUND: Immunosuppressive therapy may impact cancer risk in inflammatory bowel disease (IBD). Cancer specific data regarding risk and outcome are scarce and data for renal cell carcinoma (RCC) are lacking. We aimed(1) to identify risk factors for RCC development in IBD patients (2) to compare RCC characteristics, outcome and survival between IBD patients and the general population. METHODS: A PALGA (Dutch Pathology Registry) search was performed to establish a case group consisting of all IBD patients with incident RCC in The Netherlands (1991-2013). Cases were compared with two separate control groups: (A) with a population-based IBD cohort for identification of risk factors (B) with a RCC cohort from the general population to compare RCC characteristics and outcomes. RESULTS: 180 IBD patients with RCC were identified. Pancolitis (OR 1.8-2.5), penetrating Crohn's disease (OR 2.8), IBD related surgery (OR 3.7-4.5), male gender (OR 3.2-5.0) and older age at IBD onset (OR 1.0-1.1) were identified as independent risk factors for RCC development. IBD patients had a significantly lower age at RCC diagnosis (p < 0.001), lower N-stage (p = 0.025), lower M-stage (p = 0.020) and underwent more frequently surgical treatment for RCC (p < 0.001) compared to the general population. This translated into a better survival (p = 0.026; HR 0.7) independent of immunosuppression. CONCLUSIONS: IBD patients with a complex phenotype are at increased risk to develop RCC. They are diagnosed with RCC at a younger age and at an earlier disease stage compared to the general population. This translates into a better survival independent of immunosuppressive or anti-TNFalpha therapy.

U2 - 10.18632/oncotarget.5186

DO - 10.18632/oncotarget.5186

M3 - Article

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

ER -

Derikx LA, Nissen LH, Drenth JP, van Herpen CM, Kievit W, Verhoeven RH et al. Better survival of renal cell carcinoma in patients with inflammatory bowel disease. Oncotarget. 2015 Jan 1. https://doi.org/10.18632/oncotarget.5186