Beta 3-adrenoreceptor regulation of nitric oxide in the cardiovascular system

An L. Moens, Ronghua Yang, Vabren L. Watts, Lili A. Barouch*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Web of Science)

Abstract

The presence of a third beta-adrenergic receptor (beta 3-AR) in the cardiovascular system has challenged the classical paradigm of sympathetic regulation by beta 1- and beta 2-adrenergic receptors. While beta 3-AR's role in the cardiovascular system remains controversial, increasing evidence suggests that it serves as a "brake" in sympathetic overstimulation - it is activated at high catecholamine concentrations, producing a negative inotropic effect that antagonizes beta 1- and beta 2-AR activity. The anti-adrenergic effects induced by beta 3-AR were initially linked to nitric oxide (NO) release via endothelial NO synthase (eNOS), although more recently it has been shown under some conditions to increase NO production in the cardiovascular system via the other two NOS isoforms, namely inducible NOS (iNOS) and neuronal NOS (nNOS). We summarize recent findings regarding beta 3-AR effects on the cardiovascular system and explore its prospective as a therapeutic target, particularly focusing on its emerging role as an important mediator of NO signaling in the pathogenesis of cardiovascular disorders.
Original languageEnglish
Pages (from-to)1088-1095
JournalJournal of Molecular and Cellular Cardiology
Volume48
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Beta 3 adrenergic receptor
  • Nitric oxide synthase
  • Cardiovascular
  • Heart failure

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