Benefits of Substitution Sitting with Standing and Walking in Free-living Conditions for Cardiometabolic Risk Markers, cognition and Mood in Overweight Adults

Bernard M. F. M. Duvivier*, Nicolaas C. Schaper, Annemarie Koster, Linh van Kan, Harry P. F. Peters, Jos J. Adam, Timo Giesbrecht, Esther Kornips, Martine Hulsbosch, Paul Willems, Matthijs K. C. Hesselink, Patrick Schrauwen, Hans H. C. M. Savelberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background : We investigated whether substituting sitting with standing and self-perceived light walking in free-living conditions would improve cardiometabolic risk factors, mood, and cognition in overweight/ obese adults.

Methods : In a randomized, cross-over study, 24 (m/f: 13/11) sedentary overweight/ obese participants (64 +/- 7 years, BMI 29 +/- 2 kg/m(2)) followed two activity regimens of each 4 days in free-living conditions: "Sit": sitting 13.5 h/day, standing 1.4 h/day, self-perceived light-intensity walking 0.7 h/day; for "SitLess" these activities lasted 7.6, 4.0, and 4.3 h/day, respectively. Meals were standardized and physical activity was assessed by accelerometry (activPAL). Insulin sensitivity (expressed as Matsuda-index based on an oral glucose tolerance test), circulating lipids, blood pressure, mood (pleasantness and arousal), and cognition were assessed on the morning after the activity regimens. Quality of life and sleep were assessed on the last day of the activity regimens.

Results : We observed that AUC (0-190 min) for insulin decreased by 20% after SitLess vs. Sit [10,125 (656) vs. 12,633 (818); p = 0.006]. Insulin sensitivity improved by 16% after SitLess vs. Sit [Matsuda-index, mean (SEM): 6.45 (0.25) vs. 5.58 (0.25) respectively; p = 0.007]. Fasting triglycerides, non-HDL-cholesterol, and apolipoprotein B decreased by 32, 7, and 4% respectively, whereas HDL-cholesterol increased by 7% after SitLess vs. Sit (all p <0.01). Diastolic blood pressure was lower after SitLess vs. Sit (p <0.05). Pleasantness (as one marker of mood status) after the oral glucose tolerance test was higher after SitLess vs. Sit (p <0.05). There was no significant difference between regimens for cognition, quality of life and sleep.

Conclusions : Reducing sitting time in free-living conditions markedly improved insulin sensitivity, circulating lipids, and diastolic blood pressure. Substituting sitting with standing and self-perceived light walking is an effective strategy to improve cardiometabolic risk factors in overweight/obese subjects.

Original languageEnglish
Article number353
Number of pages9
JournalFrontiers in physiology
Volume8
DOIs
Publication statusPublished - 8 Jun 2017

Keywords

  • exercise
  • insulin sensitivity
  • light-intensity physical activity
  • lipids
  • sedentary behavior
  • sitting
  • standing
  • walking
  • DENSITY-LIPOPROTEIN CHOLESTEROL
  • HUMAN SKELETAL-MUSCLE
  • INSULIN SENSITIVITY
  • AEROBIC EXERCISE
  • SEDENTARY TIME
  • POSTPRANDIAL GLYCEMIA
  • RANDOMIZED CROSSOVER
  • ACTIVITY MONITOR
  • OBESITY
  • BREAKING

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