Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

J. Wu, P. Bostrom, L.M. Sparks, L. Ye, J. H. Choi, A. H. Giang, M. Khandekar, K. A. Virtanen, P. Nuutila, G. Schaart, K. Huang, H. Tu, W.D. van Marken Lichtenbelt, J. Hoeks, S. Enerback, P. Schrauwen, B.M. Spiegelman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential.

Original languageEnglish
Pages (from-to)366-376
Number of pages11
JournalCell
Volume150
Issue number2
DOIs
Publication statusPublished - 20 Jul 2012

Keywords

  • BROWN ADIPOSE-TISSUE
  • WHITE FAT
  • TRANSCRIPTIONAL CONTROL
  • SKELETAL-MUSCLE
  • IN-VIVO
  • IDENTIFICATION
  • PROGENITORS
  • ACTIVATION
  • INDUCTION
  • OBESITY

Cite this

Wu, J., Bostrom, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerback, S., Schrauwen, P., & Spiegelman, B. M. (2012). Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell, 150(2), 366-376. https://doi.org/10.1016/j.cell.2012.05.016