Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

J. Wu; P. Bostrom; L.M. Sparks; L. Ye; J. H. Choi; A. H. Giang; M. Khandekar; K. A. Virtanen; P. Nuutila; G. Schaart; K. Huang; H. Tu; W.D. van Marken Lichtenbelt; J. Hoeks; S. Enerback; P. Schrauwen; B.M. Spiegelman

doi:10.1016/j.cell.2012.05.016

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

J. Wu, P. Bostrom, L.M. Sparks, L. Ye, J. H. Choi, A. H. Giang, M. Khandekar, K. A. Virtanen, P. Nuutila, G. Schaart, K. Huang, H. Tu, W.D. van Marken Lichtenbelt, J. Hoeks, S. Enerback, P. Schrauwen, B.M. Spiegelman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential.

Original language	English
Pages (from-to)	366-376
Number of pages	11
Journal	Cell
Volume	150
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2012.05.016
Publication status	Published - 20 Jul 2012

Keywords

BROWN ADIPOSE-TISSUE
WHITE FAT
TRANSCRIPTIONAL CONTROL
SKELETAL-MUSCLE
IN-VIVO
IDENTIFICATION
PROGENITORS
ACTIVATION
INDUCTION
OBESITY

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Wu, J., Bostrom, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerback, S., Schrauwen, P., & Spiegelman, B. M. (2012). Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell, 150(2), 366-376. https://doi.org/10.1016/j.cell.2012.05.016

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title = "Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.",

abstract = "Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of {"}beige{"} cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential.",

keywords = "BROWN ADIPOSE-TISSUE, WHITE FAT, TRANSCRIPTIONAL CONTROL, SKELETAL-MUSCLE, IN-VIVO, IDENTIFICATION, PROGENITORS, ACTIVATION, INDUCTION, OBESITY",

author = "J. Wu and P. Bostrom and L.M. Sparks and L. Ye and Choi, {J. H.} and Giang, {A. H.} and M. Khandekar and Virtanen, {K. A.} and P. Nuutila and G. Schaart and K. Huang and H. Tu and {van Marken Lichtenbelt}, W.D. and J. Hoeks and S. Enerback and P. Schrauwen and B.M. Spiegelman",

year = "2012",

month = jul,

day = "20",

doi = "10.1016/j.cell.2012.05.016",

language = "English",

volume = "150",

pages = "366--376",

journal = "Cell",

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Wu, J, Bostrom, P, Sparks, LM, Ye, L, Choi, JH, Giang, AH, Khandekar, M, Virtanen, KA, Nuutila, P, Schaart, G, Huang, K, Tu, H, van Marken Lichtenbelt, WD , Hoeks, J, Enerback, S, Schrauwen, P & Spiegelman, BM 2012, 'Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.', Cell, vol. 150, no. 2, pp. 366-376. https://doi.org/10.1016/j.cell.2012.05.016

TY - JOUR

T1 - Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

AU - Wu, J.

AU - Bostrom, P.

AU - Sparks, L.M.

AU - Ye, L.

AU - Choi, J. H.

AU - Giang, A. H.

AU - Khandekar, M.

AU - Virtanen, K. A.

AU - Nuutila, P.

AU - Schaart, G.

AU - Huang, K.

AU - Tu, H.

AU - van Marken Lichtenbelt, W.D.

AU - Hoeks, J.

AU - Enerback, S.

AU - Schrauwen, P.

AU - Spiegelman, B.M.

PY - 2012/7/20

Y1 - 2012/7/20

N2 - Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential.

AB - Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential.

KW - BROWN ADIPOSE-TISSUE

KW - WHITE FAT

KW - TRANSCRIPTIONAL CONTROL

KW - SKELETAL-MUSCLE

KW - IN-VIVO

KW - IDENTIFICATION

KW - PROGENITORS

KW - ACTIVATION

KW - INDUCTION

KW - OBESITY

U2 - 10.1016/j.cell.2012.05.016

DO - 10.1016/j.cell.2012.05.016

M3 - Article

C2 - 22796012

SN - 0092-8674

VL - 150

SP - 366

EP - 376

JO - Cell

JF - Cell

IS - 2

ER -

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

Abstract

Keywords

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