Abstract
Intacerebroventricularly (ICV) injected streptozotocin (STREP) decreases central glucose metabolism and energy metabolism, which has also been observed in patients with dementia. In the present study we examined the behavioral (open-field behavior and two-way active avoidance learning) and biochemical (hippocampal ChAT activity) effects of STREP treatment in old Lewis rats. The results suggest that hippocampal function was affected by STREP. STREP-treated rats acquired the two-way active avoidance task faster than the control rats, which indicates that STREP treatment does not lead to a general learning deficit. Hippocampal ChAT activity was decreased in STREP-treated rats. The present results suggests also that susceptibility to STREP amy not be related to age in Lewis rats.
| Original language | English |
|---|---|
| Pages (from-to) | 833-837 |
| Number of pages | 5 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 47 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jan 1994 |