Behavioural and biochemical effects of an ICV injection of streptozotocin in old Lewis rats

Arjan Blokland; Jellemer Jolles

doi:10.1016/0091-3057(94)90284-4

Behavioural and biochemical effects of an ICV injection of streptozotocin in old Lewis rats

Arjan Blokland, Jellemer Jolles

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Abstract

Intacerebroventricularly (ICV) injected streptozotocin (STREP) decreases central glucose metabolism and energy metabolism, which has also been observed in patients with dementia. In the present study we examined the behavioral (open-field behavior and two-way active avoidance learning) and biochemical (hippocampal ChAT activity) effects of STREP treatment in old Lewis rats. The results suggest that hippocampal function was affected by STREP. STREP-treated rats acquired the two-way active avoidance task faster than the control rats, which indicates that STREP treatment does not lead to a general learning deficit. Hippocampal ChAT activity was decreased in STREP-treated rats. The present results suggests also that susceptibility to STREP amy not be related to age in Lewis rats.

Original language	English
Pages (from-to)	833-837
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	47
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(94)90284-4
Publication status	Published - 1 Jan 1994

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title = "Behavioural and biochemical effects of an ICV injection of streptozotocin in old Lewis rats",

abstract = "Intacerebroventricularly (ICV) injected streptozotocin (STREP) decreases central glucose metabolism and energy metabolism, which has also been observed in patients with dementia. In the present study we examined the behavioral (open-field behavior and two-way active avoidance learning) and biochemical (hippocampal ChAT activity) effects of STREP treatment in old Lewis rats. The results suggest that hippocampal function was affected by STREP. STREP-treated rats acquired the two-way active avoidance task faster than the control rats, which indicates that STREP treatment does not lead to a general learning deficit. Hippocampal ChAT activity was decreased in STREP-treated rats. The present results suggests also that susceptibility to STREP amy not be related to age in Lewis rats.",

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AU - Jolles, Jellemer

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AB - Intacerebroventricularly (ICV) injected streptozotocin (STREP) decreases central glucose metabolism and energy metabolism, which has also been observed in patients with dementia. In the present study we examined the behavioral (open-field behavior and two-way active avoidance learning) and biochemical (hippocampal ChAT activity) effects of STREP treatment in old Lewis rats. The results suggest that hippocampal function was affected by STREP. STREP-treated rats acquired the two-way active avoidance task faster than the control rats, which indicates that STREP treatment does not lead to a general learning deficit. Hippocampal ChAT activity was decreased in STREP-treated rats. The present results suggests also that susceptibility to STREP amy not be related to age in Lewis rats.

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DO - 10.1016/0091-3057(94)90284-4

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