Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions

Sarah Hescham, Ali Jahanshahi, Celine Meriaux, Lee Wei Lim, Arjan Blokland, Yasin Temel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Web of Science)


Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant dementia. However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the CA1 sub-region of the hippocampus, mammillothalamic tract, anterior thalamic nucleus, and entorhinal cortex in an experimental rat model of dementia. Rats with scopolamine-induced amnesia were assessed in the object location task with different DBS parameters. Moreover, anxiety-related side effects were evaluated in the elevated zero maze and open field. After sacrifice, we applied c-Fos immunohistochemistry to assess which memory-related regions were affected by DBS. When comparing all structures, DBS of the entorhinal cortex and CA1 sub-region was able to restore memory loss when a specific set of stimulation parameters was used. No anxiety-related side effects were found following DBS. The beneficial behavioral performance of CA1 DBS rats was accompanied with an activation of cells in the anterior cingulate gyrus. Therefore, we conclude that acute CM DBS restores memory loss possibly through improved attentional and cognitive processes in the limbic cortex.
Original languageEnglish
Pages (from-to)353-360
JournalBehavioural Brain Research
Publication statusPublished - 1 Oct 2015


  • Deep brain stimulation
  • Circuit of Papez
  • Memory
  • Hippocampus
  • Enthorhinal cortex

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