Motor Disturbance in ASD: A Pilot Study Showing Hypokinetic Behavior?

M. A. L. Mostert-Kerckhoffs; A. E. Willems; D. E. Tenback; J. P. Koning; P. Van Harten; W. G. Staal

doi:10.1007/s10803-019-04171-1

Motor Disturbance in ASD: A Pilot Study Showing Hypokinetic Behavior?

M. A. L. Mostert-Kerckhoffs^*, A. E. Willems, D. E. Tenback, J. P. Koning, P. Van Harten, W. G. Staal

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Data supporting theoretical models linking autism spectrum disorders (ASD) to motor disturbance are inconclusive. In the present study, children and adolescents with ASD (n=44) were compared with a matched group of typically developing individuals (n=49) on both instrumental and observational assessments of motor abnormalities. No group differences were found in the instrumental data. However, more bradykinetic motor behavior was found using an observational scale in the ASD groups. More rigid motor behavior was found in the adolescents with ASD but not in the children. Individuals with ASD show significantly more hypokinetic behavior, which may not be strictly dopaminergic in origin, but may reflect a weak central coherency in neuronal networks related to the motor system in which developmental changes are present.

Original language	English
Pages (from-to)	415-428
Number of pages	14
Journal	Journal of Autism and Developmental Disorders
Volume	50
Issue number	2
Early online date	31 Oct 2019
DOIs	https://doi.org/10.1007/s10803-019-04171-1
Publication status	Published - Feb 2020

Keywords

AUTISM
Autism spectrum disorder
CHILDREN
COMMUNICATION DEFICITS
DISORDERS
DRD3 GENE
Dyskinesia
FORCE VARIABILITY
FUNCTIONAL CONNECTIVITY
Motor disturbance
Parkinsonism
SKILLS
SPECTRUM
TARDIVE-DYSKINESIA
AUTISM SPECTRUM DISORDER
SCHIZOPHRENIA
IMPAIRMENT

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10.1007/s10803-019-04171-1

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Cite this

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title = "Motor Disturbance in ASD: A Pilot Study Showing Hypokinetic Behavior?",

abstract = "Data supporting theoretical models linking autism spectrum disorders (ASD) to motor disturbance are inconclusive. In the present study, children and adolescents with ASD (n=44) were compared with a matched group of typically developing individuals (n=49) on both instrumental and observational assessments of motor abnormalities. No group differences were found in the instrumental data. However, more bradykinetic motor behavior was found using an observational scale in the ASD groups. More rigid motor behavior was found in the adolescents with ASD but not in the children. Individuals with ASD show significantly more hypokinetic behavior, which may not be strictly dopaminergic in origin, but may reflect a weak central coherency in neuronal networks related to the motor system in which developmental changes are present.",

keywords = "AUTISM, Autism spectrum disorder, CHILDREN, COMMUNICATION DEFICITS, DISORDERS, DRD3 GENE, Dyskinesia, FORCE VARIABILITY, FUNCTIONAL CONNECTIVITY, Motor disturbance, Parkinsonism, SKILLS, SPECTRUM, TARDIVE-DYSKINESIA, AUTISM SPECTRUM DISORDER, SCHIZOPHRENIA, IMPAIRMENT",

author = "Mostert-Kerckhoffs, {M. A. L.} and Willems, {A. E.} and Tenback, {D. E.} and Koning, {J. P.} and {Van Harten}, P. and Staal, {W. G.}",

year = "2020",

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language = "English",

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T2 - A Pilot Study Showing Hypokinetic Behavior?

AU - Mostert-Kerckhoffs, M. A. L.

AU - Willems, A. E.

AU - Tenback, D. E.

AU - Koning, J. P.

AU - Van Harten, P.

AU - Staal, W. G.

PY - 2020/2

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N2 - Data supporting theoretical models linking autism spectrum disorders (ASD) to motor disturbance are inconclusive. In the present study, children and adolescents with ASD (n=44) were compared with a matched group of typically developing individuals (n=49) on both instrumental and observational assessments of motor abnormalities. No group differences were found in the instrumental data. However, more bradykinetic motor behavior was found using an observational scale in the ASD groups. More rigid motor behavior was found in the adolescents with ASD but not in the children. Individuals with ASD show significantly more hypokinetic behavior, which may not be strictly dopaminergic in origin, but may reflect a weak central coherency in neuronal networks related to the motor system in which developmental changes are present.

AB - Data supporting theoretical models linking autism spectrum disorders (ASD) to motor disturbance are inconclusive. In the present study, children and adolescents with ASD (n=44) were compared with a matched group of typically developing individuals (n=49) on both instrumental and observational assessments of motor abnormalities. No group differences were found in the instrumental data. However, more bradykinetic motor behavior was found using an observational scale in the ASD groups. More rigid motor behavior was found in the adolescents with ASD but not in the children. Individuals with ASD show significantly more hypokinetic behavior, which may not be strictly dopaminergic in origin, but may reflect a weak central coherency in neuronal networks related to the motor system in which developmental changes are present.

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KW - DISORDERS

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KW - Dyskinesia

KW - FORCE VARIABILITY

KW - FUNCTIONAL CONNECTIVITY

KW - Motor disturbance

KW - Parkinsonism

KW - SKILLS

KW - SPECTRUM

KW - TARDIVE-DYSKINESIA

KW - AUTISM SPECTRUM DISORDER

KW - SCHIZOPHRENIA

KW - IMPAIRMENT

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