Barriers and facilitators for systematically registering adverse drug reactions in electronic health records: a qualitative study with Dutch healthcare professionals

I.P.A.C. Geeven, N.T. Jessurun*, A.T.M. Wasylewicz, M. Drent, P.I. Spuls, F. Hoentjen, E.P. van Puijenbroek, H.E. Vonkeman, K.P. Grootens, M.B.A. van Doorn, B.J.F. van den Bemt, C.L. Bekkers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)


Background Systematically registering ADRs in electronic health records (EHRs) likely contribute to patient safety as it enables the exchange of drug safety data. Currently, ADRs registrations by healthcare professionals (HCPs) is suboptimal. This study aimed to identify barriers and facilitators perceived by HCPs to register ADRs systematically in EHRs. Research Design and Methods A qualitative study with individual interviews was conducted among specialist physicians and hospital pharmacists from 10 different Dutch hospitals. A semi-structured interview guide was used to identify experienced barriers and facilitators for systematically registering ADRs. Data was analyzed following thematic analysis. Themes within barriers and facilitators were aligned with the Capability-Opportunity-Motivation-Behavior (COM-B) framework. Results In total, 16 HCPs were interviewed. Identified barriers were: lack of knowledge to recognize ADRs, time constraints, inadequate IT system, lack of support, stuck in routine, and not recognizing the importance of registering ADRs. Identified facilitators were: enhanced knowledge and awareness of ADRs, functional IT systems, expanding accountability for registration, and motivation toward registering. Conclusions Barriers and facilitators for registering spanned all aspects of the COM-B model and occurred in individual, social and environmental domains. Addressing these aspects could improve the registration of ADRs and may contribute to patient safety.
Original languageEnglish
Pages (from-to)699-706
Number of pages8
JournalExpert opinion on drug safety
Issue number5
Early online date26 Jan 2022
Publication statusPublished - 4 May 2022


  • Adverse drug reaction
  • adverse drug reaction registration
  • hospitals
  • capability
  • opportunity
  • motivation
  • behavior (COM-B) model

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