Balancing Ethical Pros and Cons of Stem Cell Derived Gametes

Seppe Segers*, Heidi Mertes, Guido de Wert, Wybo Dondorp, Guido Pennings

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Web of Science)

Abstract

In this review we aim to provide an overview of the most important ethical pros and cons of stem cell derived gametes (SCD-gametes), as a contribution to the debate about reproductive tissue engineering. Derivation of gametes from stem cells holds promising applications both for research and for clinical use in assisted reproduction. We explore the ethical issues connected to gametes derived from embryonic stem cells (both patient specific and non-patient specific) as well as those related to gametes derived from induced pluripotent stem cells. The technology of SCD-gametes raises moral concerns of how reproductive autonomy relates to issues of embryo destruction, safety, access, and applications beyond clinical infertility.

Original languageEnglish
Pages (from-to)1620-1632
Number of pages13
JournalAnnals of Biomedical Engineering
Volume45
Issue number7
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Artificial gametes
  • Assisted reproductive technologies
  • Embryo research
  • Gametogenesis
  • Infertility
  • Parenthood
  • Stem cells
  • IN-VITRO EUGENICS
  • MEDICALLY ASSISTED REPRODUCTION
  • HUMAN GERM-CELLS
  • GENETIC PARENTHOOD
  • NUCLEAR TRANSFER
  • EMBRYOS
  • LAW
  • DIFFERENTIATION
  • INFERTILITY
  • TECHNOLOGY

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