Balancing Ethical Pros and Cons of Stem Cell Derived Gametes

Seppe Segers; Heidi Mertes; Guido de Wert; Wybo Dondorp; Guido Pennings

doi:10.1007/s10439-017-1793-9

Balancing Ethical Pros and Cons of Stem Cell Derived Gametes

Seppe Segers^*, Heidi Mertes, Guido de Wert, Wybo Dondorp, Guido Pennings

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this review we aim to provide an overview of the most important ethical pros and cons of stem cell derived gametes (SCD-gametes), as a contribution to the debate about reproductive tissue engineering. Derivation of gametes from stem cells holds promising applications both for research and for clinical use in assisted reproduction. We explore the ethical issues connected to gametes derived from embryonic stem cells (both patient specific and non-patient specific) as well as those related to gametes derived from induced pluripotent stem cells. The technology of SCD-gametes raises moral concerns of how reproductive autonomy relates to issues of embryo destruction, safety, access, and applications beyond clinical infertility.

Original language	English
Pages (from-to)	1620-1632
Number of pages	13
Journal	Annals of Biomedical Engineering
Volume	45
Issue number	7
DOIs	https://doi.org/10.1007/s10439-017-1793-9
Publication status	Published - Jul 2017

Keywords

Artificial gametes
Assisted reproductive technologies
Embryo research
Gametogenesis
Infertility
Parenthood
Stem cells
IN-VITRO EUGENICS
MEDICALLY ASSISTED REPRODUCTION
HUMAN GERM-CELLS
GENETIC PARENTHOOD
NUCLEAR TRANSFER
EMBRYOS
LAW
DIFFERENTIATION
INFERTILITY
TECHNOLOGY

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title = "Balancing Ethical Pros and Cons of Stem Cell Derived Gametes",

abstract = "In this review we aim to provide an overview of the most important ethical pros and cons of stem cell derived gametes (SCD-gametes), as a contribution to the debate about reproductive tissue engineering. Derivation of gametes from stem cells holds promising applications both for research and for clinical use in assisted reproduction. We explore the ethical issues connected to gametes derived from embryonic stem cells (both patient specific and non-patient specific) as well as those related to gametes derived from induced pluripotent stem cells. The technology of SCD-gametes raises moral concerns of how reproductive autonomy relates to issues of embryo destruction, safety, access, and applications beyond clinical infertility.",

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author = "Seppe Segers and Heidi Mertes and {de Wert}, Guido and Wybo Dondorp and Guido Pennings",

year = "2017",

month = jul,

doi = "10.1007/s10439-017-1793-9",

language = "English",

volume = "45",

pages = "1620--1632",

journal = "Annals of Biomedical Engineering",

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T1 - Balancing Ethical Pros and Cons of Stem Cell Derived Gametes

AU - Segers, Seppe

AU - Mertes, Heidi

AU - de Wert, Guido

AU - Dondorp, Wybo

AU - Pennings, Guido

PY - 2017/7

Y1 - 2017/7

N2 - In this review we aim to provide an overview of the most important ethical pros and cons of stem cell derived gametes (SCD-gametes), as a contribution to the debate about reproductive tissue engineering. Derivation of gametes from stem cells holds promising applications both for research and for clinical use in assisted reproduction. We explore the ethical issues connected to gametes derived from embryonic stem cells (both patient specific and non-patient specific) as well as those related to gametes derived from induced pluripotent stem cells. The technology of SCD-gametes raises moral concerns of how reproductive autonomy relates to issues of embryo destruction, safety, access, and applications beyond clinical infertility.

AB - In this review we aim to provide an overview of the most important ethical pros and cons of stem cell derived gametes (SCD-gametes), as a contribution to the debate about reproductive tissue engineering. Derivation of gametes from stem cells holds promising applications both for research and for clinical use in assisted reproduction. We explore the ethical issues connected to gametes derived from embryonic stem cells (both patient specific and non-patient specific) as well as those related to gametes derived from induced pluripotent stem cells. The technology of SCD-gametes raises moral concerns of how reproductive autonomy relates to issues of embryo destruction, safety, access, and applications beyond clinical infertility.

KW - Artificial gametes

KW - Assisted reproductive technologies

KW - Embryo research

KW - Gametogenesis

KW - Infertility

KW - Parenthood

KW - Stem cells

KW - IN-VITRO EUGENICS

KW - MEDICALLY ASSISTED REPRODUCTION

KW - HUMAN GERM-CELLS

KW - GENETIC PARENTHOOD

KW - NUCLEAR TRANSFER

KW - EMBRYOS

KW - LAW

KW - DIFFERENTIATION

KW - INFERTILITY

KW - TECHNOLOGY

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DO - 10.1007/s10439-017-1793-9

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EP - 1632

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - 7

ER -

Balancing Ethical Pros and Cons of Stem Cell Derived Gametes

Abstract

Keywords

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