Towards translational modeling of behavioral despair and its treatment in zebrafish

Yuriy M H B Kositsyn; Andrew D Volgin; Murilo S de Abreu; Konstantin A Demin; Konstantin N Zabegalov; Gleb O Maslov; Elena V Petersen; Tatiana O Kolesnikova; Tatiana Strekalova; Allan V Kalueff

doi:10.1016/j.bbr.2022.113906

Towards translational modeling of behavioral despair and its treatment in zebrafish

Yuriy M H B Kositsyn, Andrew D Volgin, Murilo S de Abreu^*, Konstantin A Demin, Konstantin N Zabegalov, Gleb O Maslov, Elena V Petersen, Tatiana O Kolesnikova, Tatiana Strekalova, Allan V Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.

Original language	English
Article number	113906
Number of pages	8
Journal	Behavioural Brain Research
Volume	430
Early online date	27 Apr 2022
DOIs	https://doi.org/10.1016/j.bbr.2022.113906
Publication status	Published - 26 Jul 2022

Keywords

ACUTE RESTRAINT STRESS
AFFECTIVE-DISORDERS
ANIMAL-MODEL
ANXIETY-LIKE BEHAVIOR
Animal models
Antidepressant
Behavior
COGNITIVE DEFICIT
Despair
EMERGING MODEL
HPA AXIS
LEARNED HELPLESSNESS
PREFRONTAL CORTEX
TAIL SUSPENSION TEST
Zebrafish

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10.1016/j.bbr.2022.113906

Cite this

@article{b6c6a70e054e4368834d24b69add62a9,

title = "Towards translational modeling of behavioral despair and its treatment in zebrafish",

abstract = "Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.",

keywords = "ACUTE RESTRAINT STRESS, AFFECTIVE-DISORDERS, ANIMAL-MODEL, ANXIETY-LIKE BEHAVIOR, Animal models, Antidepressant, Behavior, COGNITIVE DEFICIT, Despair, EMERGING MODEL, HPA AXIS, LEARNED HELPLESSNESS, PREFRONTAL CORTEX, TAIL SUSPENSION TEST, Zebrafish",

author = "Kositsyn, {Yuriy M H B} and Volgin, {Andrew D} and {de Abreu}, {Murilo S} and Demin, {Konstantin A} and Zabegalov, {Konstantin N} and Maslov, {Gleb O} and Petersen, {Elena V} and Kolesnikova, {Tatiana O} and Tatiana Strekalova and Kalueff, {Allan V}",

note = "Copyright {\textcopyright} 2022. Published by Elsevier B.V.",

year = "2022",

month = jul,

day = "26",

doi = "10.1016/j.bbr.2022.113906",

language = "English",

volume = "430",

journal = "Behavioural Brain Research",

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publisher = "Elsevier Science",

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T1 - Towards translational modeling of behavioral despair and its treatment in zebrafish

AU - Kositsyn, Yuriy M H B

AU - Volgin, Andrew D

AU - de Abreu, Murilo S

AU - Demin, Konstantin A

AU - Zabegalov, Konstantin N

AU - Maslov, Gleb O

AU - Petersen, Elena V

AU - Kolesnikova, Tatiana O

AU - Strekalova, Tatiana

AU - Kalueff, Allan V

PY - 2022/7/26

Y1 - 2022/7/26

N2 - Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.

AB - Depression is a widespread and severely debilitating neuropsychiatric disorder whose key clinical symptoms include low mood, anhedonia and despair (the inability or unwillingness to overcome stressors). Experimental animal models are widely used to improve our mechanistic understanding of depression pathogenesis, and to develop novel antidepressant therapies. In rodents, various experimental models of 'behavioral despair' have already been developed and rigorously validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of depression and other related affective disorders. Here, we critically discuss the developing potential and important translational implications of zebrafish models for studying despair and its mechanisms, and the utility of such aquatic models for antidepressant drug screening.

KW - ACUTE RESTRAINT STRESS

KW - AFFECTIVE-DISORDERS

KW - ANIMAL-MODEL

KW - ANXIETY-LIKE BEHAVIOR

KW - Animal models

KW - Antidepressant

KW - Behavior

KW - COGNITIVE DEFICIT

KW - Despair

KW - EMERGING MODEL

KW - HPA AXIS

KW - LEARNED HELPLESSNESS

KW - PREFRONTAL CORTEX

KW - TAIL SUSPENSION TEST

KW - Zebrafish

U2 - 10.1016/j.bbr.2022.113906

DO - 10.1016/j.bbr.2022.113906

M3 - Article

C2 - 35489477

SN - 0166-4328

VL - 430

JO - Behavioural Brain Research

JF - Behavioural Brain Research

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ER -