Daily energy expenditure through the human life course

H. Pontzer; Y. Yamada; H. Sagayama; P.N. Ainslie; L.F. Andersen; L.J. Anderson; L. Arab; I. Baddou; K. Bedu-Addo; E.E. Blaak; S. Blanc; A.G. Bonomi; C.V.C. Bouten; P. Bovet; M.S. Buchowski; N.F. Butte; S.G. Camps; G.L. Close; J.A. Cooper; R. Cooper; S.K. Das; L.R. Dugas; U. Ekelund; S. Entringer; T. Forrester; B.W. Fudge; A.H. Goris; M. Gurven; C. Hambly; A. El Hamdouchi; M.B. Hoos; S.M. Hu; N. Joonas; A.M. Joosen; P. Katzmarzyk; K.P. Kempen; M. Kimura; W.E. Kraus; R.F. Kushner; E.V. Lambert; W.R. Leonard; N. Lessan; C. Martin; A.C. Medin; E.P. Meijer; J.C. Morehen; J.P. Morton; M.L. Neuhouser; T.A. Nicklas; R.M. Ojiambo; Guy Plasqui; Klaas Westerterp; IAEA DLW Database Consortium; Edgar A. van Mil

doi:10.1126/science.abe5017

Daily energy expenditure through the human life course

H. Pontzer^*, Y. Yamada^*, H. Sagayama^*, P.N. Ainslie, L.F. Andersen, L.J. Anderson, L. Arab, I. Baddou, K. Bedu-Addo, E.E. Blaak, S. Blanc, A.G. Bonomi, C.V.C. Bouten, P. Bovet, M.S. Buchowski, N.F. Butte, S.G. Camps, G.L. Close, J.A. Cooper, R. CooperS.K. Das, L.R. Dugas, U. Ekelund, S. Entringer, T. Forrester, B.W. Fudge, A.H. Goris, M. Gurven, C. Hambly, A. El Hamdouchi, M.B. Hoos, S.M. Hu, N. Joonas, A.M. Joosen, P. Katzmarzyk, K.P. Kempen, M. Kimura, W.E. Kraus, R.F. Kushner, E.V. Lambert, W.R. Leonard, N. Lessan, C. Martin, A.C. Medin, E.P. Meijer, J.C. Morehen, J.P. Morton, M.L. Neuhouser, T.A. Nicklas, R.M. Ojiambo, Guy Plasqui, Klaas Westerterp, IAEA DLW Database Consortium, Edgar A. van Mil

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to similar to 50% above adult values at similar to 1 year; declines slowly to adult levels by similar to 20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Original language	English
Pages (from-to)	808-812
Number of pages	34
Journal	Science
Volume	373
Issue number	6556
DOIs	https://doi.org/10.1126/science.abe5017
Publication status	Published - 13 Aug 2021

Keywords

CELLULAR-LEVEL APPROACH
BASAL METABOLIC-RATE
PHYSICAL-ACTIVITY
LONGITUDINAL ASSESSMENT
SLEEP DURATION
ORGAN SIZE
WATER
CHILDREN
REQUIREMENTS
DEPOSITION

Access to Document

10.1126/science.abe5017

https://researchonline.ljmu.ac.uk/id/eprint/15386/1/Pontzer%20et%20al%202021%20Accepted.pdf

Cite this

Pontzer, H., Yamada, Y., Sagayama, H., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G., Close, G. L., Cooper, J. A., ... van Mil, E. A. (2021). Daily energy expenditure through the human life course. Science, 373(6556), 808-812. https://doi.org/10.1126/science.abe5017

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title = "Daily energy expenditure through the human life course",

abstract = "Total daily energy expenditure ({"}total expenditure{"}) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to similar to 50% above adult values at similar to 1 year; declines slowly to adult levels by similar to 20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.",

keywords = "CELLULAR-LEVEL APPROACH, BASAL METABOLIC-RATE, PHYSICAL-ACTIVITY, LONGITUDINAL ASSESSMENT, SLEEP DURATION, ORGAN SIZE, WATER, CHILDREN, REQUIREMENTS, DEPOSITION",

author = "H. Pontzer and Y. Yamada and H. Sagayama and P.N. Ainslie and L.F. Andersen and L.J. Anderson and L. Arab and I. Baddou and K. Bedu-Addo and E.E. Blaak and S. Blanc and A.G. Bonomi and C.V.C. Bouten and P. Bovet and M.S. Buchowski and N.F. Butte and S.G. Camps and G.L. Close and J.A. Cooper and R. Cooper and S.K. Das and L.R. Dugas and U. Ekelund and S. Entringer and T. Forrester and B.W. Fudge and A.H. Goris and M. Gurven and C. Hambly and {El Hamdouchi}, A. and M.B. Hoos and S.M. Hu and N. Joonas and A.M. Joosen and P. Katzmarzyk and K.P. Kempen and M. Kimura and W.E. Kraus and R.F. Kushner and E.V. Lambert and W.R. Leonard and N. Lessan and C. Martin and A.C. Medin and E.P. Meijer and J.C. Morehen and J.P. Morton and M.L. Neuhouser and T.A. Nicklas and R.M. Ojiambo and Guy Plasqui and Klaas Westerterp and {IAEA DLW Database Consortium} and {van Mil}, {Edgar A.}",

year = "2021",

month = aug,

day = "13",

doi = "10.1126/science.abe5017",

language = "English",

volume = "373",

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journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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Pontzer, H, Yamada, Y, Sagayama, H, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SG, Close, GL, Cooper, JA, Cooper, R, Das, SK, Dugas, LR, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, SM, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Martin, C, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Neuhouser, ML, Nicklas, TA, Ojiambo, RM, Plasqui, G, Westerterp, K, IAEA DLW Database Consortium & van Mil, EA 2021, 'Daily energy expenditure through the human life course', Science, vol. 373, no. 6556, pp. 808-812. https://doi.org/10.1126/science.abe5017

TY - JOUR

T1 - Daily energy expenditure through the human life course

AU - Pontzer, H.

AU - Yamada, Y.

AU - Sagayama, H.

AU - Ainslie, P.N.

AU - Andersen, L.F.

AU - Anderson, L.J.

AU - Arab, L.

AU - Baddou, I.

AU - Bedu-Addo, K.

AU - Blaak, E.E.

AU - Blanc, S.

AU - Bonomi, A.G.

AU - Bouten, C.V.C.

AU - Bovet, P.

AU - Buchowski, M.S.

AU - Butte, N.F.

AU - Camps, S.G.

AU - Close, G.L.

AU - Cooper, J.A.

AU - Cooper, R.

AU - Das, S.K.

AU - Dugas, L.R.

AU - Ekelund, U.

AU - Entringer, S.

AU - Forrester, T.

AU - Fudge, B.W.

AU - Goris, A.H.

AU - Gurven, M.

AU - Hambly, C.

AU - El Hamdouchi, A.

AU - Hoos, M.B.

AU - Hu, S.M.

AU - Joonas, N.

AU - Joosen, A.M.

AU - Katzmarzyk, P.

AU - Kempen, K.P.

AU - Kimura, M.

AU - Kraus, W.E.

AU - Kushner, R.F.

AU - Lambert, E.V.

AU - Leonard, W.R.

AU - Lessan, N.

AU - Martin, C.

AU - Medin, A.C.

AU - Meijer, E.P.

AU - Morehen, J.C.

AU - Morton, J.P.

AU - Neuhouser, M.L.

AU - Nicklas, T.A.

AU - Ojiambo, R.M.

AU - Plasqui, Guy

AU - Westerterp, Klaas

AU - IAEA DLW Database Consortium

AU - van Mil, Edgar A.

PY - 2021/8/13

Y1 - 2021/8/13

N2 - Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to similar to 50% above adult values at similar to 1 year; declines slowly to adult levels by similar to 20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

AB - Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to similar to 50% above adult values at similar to 1 year; declines slowly to adult levels by similar to 20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

KW - CELLULAR-LEVEL APPROACH

KW - BASAL METABOLIC-RATE

KW - PHYSICAL-ACTIVITY

KW - LONGITUDINAL ASSESSMENT

KW - SLEEP DURATION

KW - ORGAN SIZE

KW - WATER

KW - CHILDREN

KW - REQUIREMENTS

KW - DEPOSITION

U2 - 10.1126/science.abe5017

DO - 10.1126/science.abe5017

M3 - Article

C2 - 34385400

SN - 0036-8075

VL - 373

SP - 808

EP - 812

JO - Science

JF - Science

IS - 6556

ER -