TY - JOUR
T1 - Multi-Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
AU - Li, Xin
AU - Sun, Haitao
AU - Li, Helin
AU - Hu, Chaolei
AU - Luo, Yu
AU - Shi, Xiangyang
AU - Pich, Andrij
N1 - Funding Information:
X.L. and H.S. contributed equally to this work. This research was financially supported by the Sino-German Center for Research Promotion (GZ1505), Deutsche Forschungsgemeinschaft (SFB 985, Functional Microgels and Microgel Systems), National Natural Science Foundation of China (81761148028), Science and Technology Commission of Shanghai Municipality (19XD1400100), and China Scholarship Council (for X.L.). The authors would like to especial thank Silke Reider for STEM images. Open access funding enabled and organized by Projekt DEAL.
Publisher Copyright:
© 2021 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH
PY - 2021/6
Y1 - 2021/6
N2 - The facile preparation, modular design, and multi-responsiveness are extremely critical for developing pervasive nanoplatforms to meet heterogeneous applications. Here, cationic nanogels (NGs) are modularly engineered with tunable responsiveness, versatility, and biodegradation. Cationic PVCL-based NGs with core/shell structure are fabricated by facile one-step synthesis. The formed PVCL-NH2 NGs exhibit uniform size, thermal/pH dual-responsive behaviors, and redox-triggered degradation. Moreover, the NGs can be employed to modify or/and load with various functional agents to construct multipurpose nanoplatforms in a modular manner. Notably, the novel hybrid structure with copper sulfide (CuS) NPs loaded in the NGs shell is prepared, which leads to higher photothermal conversion efficiency (31.1%) than other CuS randomly loaded NGs reported. By personalized tailoring, these functionalized NGs display fluorescent property, r(1) relaxivity, strong near-infrared (NIR) absorption, good biocompatibility, and targeting specificity. The superior photothermal effect of hybrid NGs (CuS@NGs-LA) is presented under NIR II over NIR I. Importantly, hybrid NGs encapsulated doxorubicin (CuS@NGs-LA/DOX) show endogenous pH/redox and exogenous NIR multi-triggered drug release for efficient photothermal-chemotherapy, which can completely eliminate advanced tumors and effectively inhibit recurrence. Overall, the pervasive nanoplatforms based on intelligent cationic NGs with tunable responsiveness, versatility, and biodegradation are developed by engineered modular strategy for precision medicine applications.
AB - The facile preparation, modular design, and multi-responsiveness are extremely critical for developing pervasive nanoplatforms to meet heterogeneous applications. Here, cationic nanogels (NGs) are modularly engineered with tunable responsiveness, versatility, and biodegradation. Cationic PVCL-based NGs with core/shell structure are fabricated by facile one-step synthesis. The formed PVCL-NH2 NGs exhibit uniform size, thermal/pH dual-responsive behaviors, and redox-triggered degradation. Moreover, the NGs can be employed to modify or/and load with various functional agents to construct multipurpose nanoplatforms in a modular manner. Notably, the novel hybrid structure with copper sulfide (CuS) NPs loaded in the NGs shell is prepared, which leads to higher photothermal conversion efficiency (31.1%) than other CuS randomly loaded NGs reported. By personalized tailoring, these functionalized NGs display fluorescent property, r(1) relaxivity, strong near-infrared (NIR) absorption, good biocompatibility, and targeting specificity. The superior photothermal effect of hybrid NGs (CuS@NGs-LA) is presented under NIR II over NIR I. Importantly, hybrid NGs encapsulated doxorubicin (CuS@NGs-LA/DOX) show endogenous pH/redox and exogenous NIR multi-triggered drug release for efficient photothermal-chemotherapy, which can completely eliminate advanced tumors and effectively inhibit recurrence. Overall, the pervasive nanoplatforms based on intelligent cationic NGs with tunable responsiveness, versatility, and biodegradation are developed by engineered modular strategy for precision medicine applications.
KW - cationic nanogels
KW - modular engineering
KW - multi‐
KW - responsiveness
KW - theranostics
KW - DRUG
KW - MICROGELS
KW - DELIVERY
U2 - 10.1002/adfm.202100227
DO - 10.1002/adfm.202100227
M3 - Article
SN - 1616-301X
VL - 31
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 26
M1 - 2100227
ER -