TY - JOUR
T1 - Habitual Intake of Dietary Advanced Glycation End Products Is Not Associated with Arterial Stiffness of the Aorta and Carotid Artery in Adults: The Maastricht Study
AU - Linkens, A.M.A.
AU - Eussen, S.J.M.P.
AU - Houben, A.J.H.M.
AU - Kroon, A.A.
AU - Schram, M.T.
AU - Reesink, K.D.
AU - Dagnelie, P.C.
AU - Henry, R.M.A.
AU - van Greevenbroek, M.
AU - Wesselius, A.
AU - Stehouwer, C.D.A.
AU - Schalkwijk, C.G.
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Background: Advanced glycation end products (AGEs), a heterogeneous group of bioactive compounds, are thought to contribute to arterial stiffness, which in turn is a causal factor in the pathogenesis of stroke, myocardial infarction, and heart failure. Whether AGEs derived from food also contribute to arterial stiffness is not clear.Objectives: We investigated whether higher intake of dietary AGEs is associated with arterial stiffness.Methods: In this cross-sectional observational study in 2255 participants of The Maastricht Study (mean +/- SD age: 60 +/- 8 y, 51% male, mean +/- SD BMI: 26.9 +/- 4.4 kg/m(2), n = 1326 normal glucose metabolism, n = 341 prediabetes, and n = 585 type 2 diabetes mellitus), we estimated intake of the dietary AGEs N-epsilon-(carboxymethyl)lysine (CML), N-epsilon-(1-carboxyethyl)lysine (CEL), and N-delta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) by a validated FFQ coupled to our ultra-performance liquid chromatography tandem mass spectrometry dietary AGE database. Arterial stiffness was determined using carotid-femoral pulse wave velocity (cfPWV), carotid distensibility coefficient (DC), and carotid Young's elastic modulus (YEM). We performed multiple linear regression analyses adjusting for potential confounders (demographic, hemodynamic, cardiovascular, and dietary factors).Results: In the fully adjusted models we observed no statistically significant associations between intake of the dietary AGEs CML, CEL, and MG-H1 and arterial stiffness expressed as cfPWV, carotid DC, and carotid YEM.Conclusions: In adults aged 40-75 y, habitual intake of the dietary AGEs CML, CEL, and MG-H1 is not associated with arterial stiffness measured as cfPWV, carotid DC, or carotid YEM.
AB - Background: Advanced glycation end products (AGEs), a heterogeneous group of bioactive compounds, are thought to contribute to arterial stiffness, which in turn is a causal factor in the pathogenesis of stroke, myocardial infarction, and heart failure. Whether AGEs derived from food also contribute to arterial stiffness is not clear.Objectives: We investigated whether higher intake of dietary AGEs is associated with arterial stiffness.Methods: In this cross-sectional observational study in 2255 participants of The Maastricht Study (mean +/- SD age: 60 +/- 8 y, 51% male, mean +/- SD BMI: 26.9 +/- 4.4 kg/m(2), n = 1326 normal glucose metabolism, n = 341 prediabetes, and n = 585 type 2 diabetes mellitus), we estimated intake of the dietary AGEs N-epsilon-(carboxymethyl)lysine (CML), N-epsilon-(1-carboxyethyl)lysine (CEL), and N-delta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) by a validated FFQ coupled to our ultra-performance liquid chromatography tandem mass spectrometry dietary AGE database. Arterial stiffness was determined using carotid-femoral pulse wave velocity (cfPWV), carotid distensibility coefficient (DC), and carotid Young's elastic modulus (YEM). We performed multiple linear regression analyses adjusting for potential confounders (demographic, hemodynamic, cardiovascular, and dietary factors).Results: In the fully adjusted models we observed no statistically significant associations between intake of the dietary AGEs CML, CEL, and MG-H1 and arterial stiffness expressed as cfPWV, carotid DC, and carotid YEM.Conclusions: In adults aged 40-75 y, habitual intake of the dietary AGEs CML, CEL, and MG-H1 is not associated with arterial stiffness measured as cfPWV, carotid DC, or carotid YEM.
KW - dietary advanced glycation end products
KW - arterial stiffness
KW - aortic stiffness
KW - carotid stiffness
KW - ultra-performance liquid chromatography tandem mass spectrometry
KW - PULSE-WAVE VELOCITY
KW - EXPERT CONSENSUS DOCUMENT
KW - SERUM PENTOSIDINE
KW - FOOD
KW - ENDPRODUCTS
KW - MORTALITY
KW - INDEX
KW - CARBOXYMETHYLLYSINE
KW - AUTOFLUORESCENCE
KW - COMPLICATIONS
U2 - 10.1093/jn/nxab097
DO - 10.1093/jn/nxab097
M3 - Article
C2 - 33982103
SN - 0022-3166
VL - 151
SP - 1886
EP - 1893
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 7
ER -