Avidity of anti-beta 2-glycoprotein I antibodies in patients with antiphospholipid syndrome

S. Cucnik; T. Kveder; A. Artenjak; Z. Ulcova Gallova; J. Swadzba; J. Musial; T. Iwaniec; L. Stojanovich; C. Alessandri; G. Valesini; T. Avcin; J. W. Cohen Tervaert; B. Rozman; B. Bozic

doi:10.1177/0961203312440057

Avidity of anti-beta 2-glycoprotein I antibodies in patients with antiphospholipid syndrome

S. Cucnik^*, T. Kveder, A. Artenjak, Z. Ulcova Gallova, J. Swadzba, J. Musial, T. Iwaniec, L. Stojanovich, C. Alessandri, G. Valesini, T. Avcin, J. W. Cohen Tervaert, B. Rozman, B. Bozic

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Antibodies against beta(2)-glycoprotein I (anti-beta(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-beta(2)GPI antibodies. Our results confirmed that high avidity anti-beta(2)GPI are associated with thrombosis and APS, while in low avidity anti-beta(2)GPI group nonAPS (predominantly systemic lupus erythematosus) patients prevailed. Lupus (2012) 21, 764-765.

Original language	English
Pages (from-to)	764-765
Journal	Lupus
Volume	21
Issue number	7
DOIs	https://doi.org/10.1177/0961203312440057
Publication status	Published - Jun 2012

Keywords

anti-beta 2-glycoprotein I antibodies
avidity
chaotropic test
thrombosis

Access to Document

10.1177/0961203312440057

Cite this

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title = "Avidity of anti-beta 2-glycoprotein I antibodies in patients with antiphospholipid syndrome",

abstract = "Antibodies against beta(2)-glycoprotein I (anti-beta(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-beta(2)GPI antibodies. Our results confirmed that high avidity anti-beta(2)GPI are associated with thrombosis and APS, while in low avidity anti-beta(2)GPI group nonAPS (predominantly systemic lupus erythematosus) patients prevailed. Lupus (2012) 21, 764-765.",

keywords = "anti-beta 2-glycoprotein I antibodies, avidity, chaotropic test, thrombosis",

author = "S. Cucnik and T. Kveder and A. Artenjak and Gallova, {Z. Ulcova} and J. Swadzba and J. Musial and T. Iwaniec and L. Stojanovich and C. Alessandri and G. Valesini and T. Avcin and Tervaert, {J. W. Cohen} and B. Rozman and B. Bozic",

year = "2012",

month = jun,

doi = "10.1177/0961203312440057",

language = "English",

volume = "21",

pages = "764--765",

journal = "Lupus",

issn = "0961-2033",

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TY - JOUR

T1 - Avidity of anti-beta 2-glycoprotein I antibodies in patients with antiphospholipid syndrome

AU - Cucnik, S.

AU - Kveder, T.

AU - Artenjak, A.

AU - Gallova, Z. Ulcova

AU - Swadzba, J.

AU - Musial, J.

AU - Iwaniec, T.

AU - Stojanovich, L.

AU - Alessandri, C.

AU - Valesini, G.

AU - Avcin, T.

AU - Tervaert, J. W. Cohen

AU - Rozman, B.

AU - Bozic, B.

PY - 2012/6

Y1 - 2012/6

N2 - Antibodies against beta(2)-glycoprotein I (anti-beta(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-beta(2)GPI antibodies. Our results confirmed that high avidity anti-beta(2)GPI are associated with thrombosis and APS, while in low avidity anti-beta(2)GPI group nonAPS (predominantly systemic lupus erythematosus) patients prevailed. Lupus (2012) 21, 764-765.

AB - Antibodies against beta(2)-glycoprotein I (anti-beta(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-beta(2)GPI antibodies. Our results confirmed that high avidity anti-beta(2)GPI are associated with thrombosis and APS, while in low avidity anti-beta(2)GPI group nonAPS (predominantly systemic lupus erythematosus) patients prevailed. Lupus (2012) 21, 764-765.

KW - anti-beta 2-glycoprotein I antibodies

KW - avidity

KW - chaotropic test

KW - thrombosis

U2 - 10.1177/0961203312440057

DO - 10.1177/0961203312440057

M3 - Article

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SN - 0961-2033

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SP - 764

EP - 765

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