Avidity of anti-beta 2-glycoprotein I antibodies in patients with antiphospholipid syndrome

S. Cucnik*, T. Kveder, A. Artenjak, Z. Ulcova Gallova, J. Swadzba, J. Musial, T. Iwaniec, L. Stojanovich, C. Alessandri, G. Valesini, T. Avcin, J. W. Cohen Tervaert, B. Rozman, B. Bozic

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Web of Science)

Abstract

Antibodies against beta(2)-glycoprotein I (anti-beta(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-beta(2)GPI antibodies. Our results confirmed that high avidity anti-beta(2)GPI are associated with thrombosis and APS, while in low avidity anti-beta(2)GPI group nonAPS (predominantly systemic lupus erythematosus) patients prevailed. Lupus (2012) 21, 764-765.
Original languageEnglish
Pages (from-to)764-765
JournalLupus
Volume21
Issue number7
DOIs
Publication statusPublished - Jun 2012

Keywords

  • anti-beta 2-glycoprotein I antibodies
  • avidity
  • chaotropic test
  • thrombosis

Cite this