Automated auditory brainstem response in preterm newborns with histological chorioamnionitis

A.L. Smit*, J.V. Been, L.J.I. Zimmermann, R.F. Kornelisse, P. Andriessen, S.F. Vanterpool, M.P.H. Bischoff, R.J. Stokroos, R.R. de Krijger, B. Kremer, B.W. Kramer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


OBJECTIVE: We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome. METHODS: Two cohorts of very preterm newborns (n = 548, gestational age </= 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome. RESULTS: In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03). CONCLUSIONS: Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.
Original languageEnglish
Pages (from-to)1864-1869
Number of pages6
JournalJournal of Maternal-Fetal & Neonatal Medicine
Issue number15
Publication statusPublished - 1 Jan 2015


  • Automated auditory brainstem response
  • chorioamnionitis
  • hearing screening
  • preterm infants
  • AGE


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