Autologous platelet-derived growth factors (platelet-rich plasma) as an adjunct to mucosal advancement flap in high cryptoglandular perianal fistulae: a pilot study

S.J. van der Hagen, C.G.M.I. Baeten, P.B. Soeters, W.G. van Gemert

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

AIM: The aim of this study was to explore autologous platelet-rich plasma as an adjunct to the staged mucosal advancement flap in the treatment of perianal fistulae. METHOD: Between February 2006 and May 2007, 10 patients with fistula tracts transversing from the middle-third or upper part of the anal sphincter were treated for at least 3 months with noncutting setons prior to definitive closure by autologous platelet-rich plasma as an adjunct to a mucosal advancement flap. Five patients smoked tobacco. RESULTS: The study group consisted of six women and four men with a median age of 44 (range 30-75) years and a median follow up of 26 (range 17-32) months. One (10%) patient had a recurrent fistula. No new continence disorders developed after definitive treatment in both groups. CONCLUSION: Platelet-rich plasma as an adjunct to a staged mucosal advancement flap for the treatment of perianal cryptoglandular fistulae is a promising treatment modality and seems to establish a high healing rate.
Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalColorectal Disease
Volume13
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Growth factors
  • mucosal advancement flap
  • platelet-rich plasma
  • COMPLEX ANAL FISTULAS
  • FIBRIN GLUE
  • TRANSSPHINCTERIC FISTULAS
  • REPAIR
  • GEL
  • SMOKING
  • BONE
  • SURGERY
  • REGENERATION
  • GRAFTS

Cite this

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title = "Autologous platelet-derived growth factors (platelet-rich plasma) as an adjunct to mucosal advancement flap in high cryptoglandular perianal fistulae: a pilot study",
abstract = "AIM: The aim of this study was to explore autologous platelet-rich plasma as an adjunct to the staged mucosal advancement flap in the treatment of perianal fistulae. METHOD: Between February 2006 and May 2007, 10 patients with fistula tracts transversing from the middle-third or upper part of the anal sphincter were treated for at least 3 months with noncutting setons prior to definitive closure by autologous platelet-rich plasma as an adjunct to a mucosal advancement flap. Five patients smoked tobacco. RESULTS: The study group consisted of six women and four men with a median age of 44 (range 30-75) years and a median follow up of 26 (range 17-32) months. One (10{\%}) patient had a recurrent fistula. No new continence disorders developed after definitive treatment in both groups. CONCLUSION: Platelet-rich plasma as an adjunct to a staged mucosal advancement flap for the treatment of perianal cryptoglandular fistulae is a promising treatment modality and seems to establish a high healing rate.",
keywords = "Growth factors, mucosal advancement flap, platelet-rich plasma, COMPLEX ANAL FISTULAS, FIBRIN GLUE, TRANSSPHINCTERIC FISTULAS, REPAIR, GEL, SMOKING, BONE, SURGERY, REGENERATION, GRAFTS",
author = "{van der Hagen}, S.J. and C.G.M.I. Baeten and P.B. Soeters and {van Gemert}, W.G.",
year = "2011",
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doi = "10.1111/j.1463-1318.2009.01991.x",
language = "English",
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journal = "Colorectal Disease",
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Autologous platelet-derived growth factors (platelet-rich plasma) as an adjunct to mucosal advancement flap in high cryptoglandular perianal fistulae: a pilot study. / van der Hagen, S.J.; Baeten, C.G.M.I.; Soeters, P.B.; van Gemert, W.G.

In: Colorectal Disease, Vol. 13, No. 2, 02.2011, p. 215-218.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Autologous platelet-derived growth factors (platelet-rich plasma) as an adjunct to mucosal advancement flap in high cryptoglandular perianal fistulae: a pilot study

AU - van der Hagen, S.J.

AU - Baeten, C.G.M.I.

AU - Soeters, P.B.

AU - van Gemert, W.G.

PY - 2011/2

Y1 - 2011/2

N2 - AIM: The aim of this study was to explore autologous platelet-rich plasma as an adjunct to the staged mucosal advancement flap in the treatment of perianal fistulae. METHOD: Between February 2006 and May 2007, 10 patients with fistula tracts transversing from the middle-third or upper part of the anal sphincter were treated for at least 3 months with noncutting setons prior to definitive closure by autologous platelet-rich plasma as an adjunct to a mucosal advancement flap. Five patients smoked tobacco. RESULTS: The study group consisted of six women and four men with a median age of 44 (range 30-75) years and a median follow up of 26 (range 17-32) months. One (10%) patient had a recurrent fistula. No new continence disorders developed after definitive treatment in both groups. CONCLUSION: Platelet-rich plasma as an adjunct to a staged mucosal advancement flap for the treatment of perianal cryptoglandular fistulae is a promising treatment modality and seems to establish a high healing rate.

AB - AIM: The aim of this study was to explore autologous platelet-rich plasma as an adjunct to the staged mucosal advancement flap in the treatment of perianal fistulae. METHOD: Between February 2006 and May 2007, 10 patients with fistula tracts transversing from the middle-third or upper part of the anal sphincter were treated for at least 3 months with noncutting setons prior to definitive closure by autologous platelet-rich plasma as an adjunct to a mucosal advancement flap. Five patients smoked tobacco. RESULTS: The study group consisted of six women and four men with a median age of 44 (range 30-75) years and a median follow up of 26 (range 17-32) months. One (10%) patient had a recurrent fistula. No new continence disorders developed after definitive treatment in both groups. CONCLUSION: Platelet-rich plasma as an adjunct to a staged mucosal advancement flap for the treatment of perianal cryptoglandular fistulae is a promising treatment modality and seems to establish a high healing rate.

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KW - SURGERY

KW - REGENERATION

KW - GRAFTS

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