Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus

J. Damoiseaux*, J. van Beers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Autoantibodies, in particular anti-dsDNA antibodies, are increasingly used for diagnosis, classification and follow-up of patients with SLE. Since standardization of autoantibody assays is a major challenge, more attention should be paid to harmonization initiatives and better definition of required test characteristics in classification criteria. For diagnosis and follow-up separate multi-center studies are required to establish test characteristics of distinct immuno-assays for both purposes. Finally, such studies should consider not to evaluate SLE as a single disease, but as a disease with distinct subtypes.
Original languageEnglish
Article number100191
Number of pages5
JournalJournal of Translational Autoimmunity
Volume6
Issue number1
DOIs
Publication statusPublished - 2023

Keywords

  • Systemic lupus erythematosus
  • anti-dsDNA
  • Biomarker
  • Lupus nephritis
  • ANTI-C1Q AUTOANTIBODIES
  • REVISED CRITERIA
  • PREDICTIVE-VALUE
  • ANTIBODIES
  • SPECIFICITY
  • BINDING

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