Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease

Rob P. W. Rouhl*, Robert J. van Oostenbrugge, Ruud O. M. F. I. H. Theunissen, Iris L. H. Knottnerus, Julie Staals, Leon H. G. Henskens, Abraham A. Kroon, Peter W. de Leeuw, Jan Lodder, Jan Willem Cohen Tervaert, Jan G. M. C. Damoiseaux

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background and Purpose-Oxidized low-density lipoprotein (oxLDL) induces endothelial dysfunction and antibody formation. Because endothelial dysfunction is involved in cerebral small vessel disease (CSVD) (dilated Virchow Robin spaces, lacunar infarcts, and white matter lesions), oxLDL antibodies could play a role in CSVD pathogenesis. Therefore, we studied oxLDL antibodies in patients with high prevalence of CSVD: lacunar stroke patients and essential hypertensive patients. Methods-A total of 158 lacunar stroke patients, 158 hypertensive patients, and 43 healthy controls were included. We determined levels of IgG and IgM against hypochlorite (HOCl) and malondialdehyde (MDA) oxLDL using ELISA (values in optical density). Results-Patients with CSVD had higher levels of IgG-HOCl-oxLDL (0.77 versus 0.70; P
Original languageEnglish
Pages (from-to)2687-2689
JournalStroke
Volume41
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • lacunar infarct
  • stroke
  • white matter lesions
  • oxidized low-density lipoproteins
  • hypertension

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