TY - JOUR
T1 - Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease
AU - Rouhl, Rob P. W.
AU - van Oostenbrugge, Robert J.
AU - Theunissen, Ruud O. M. F. I. H.
AU - Knottnerus, Iris L. H.
AU - Staals, Julie
AU - Henskens, Leon H. G.
AU - Kroon, Abraham A.
AU - de Leeuw, Peter W.
AU - Lodder, Jan
AU - Tervaert, Jan Willem Cohen
AU - Damoiseaux, Jan G. M. C.
PY - 2010/11
Y1 - 2010/11
N2 - Background and Purpose-Oxidized low-density lipoprotein (oxLDL) induces endothelial dysfunction and antibody formation. Because endothelial dysfunction is involved in cerebral small vessel disease (CSVD) (dilated Virchow Robin spaces, lacunar infarcts, and white matter lesions), oxLDL antibodies could play a role in CSVD pathogenesis. Therefore, we studied oxLDL antibodies in patients with high prevalence of CSVD: lacunar stroke patients and essential hypertensive patients. Methods-A total of 158 lacunar stroke patients, 158 hypertensive patients, and 43 healthy controls were included. We determined levels of IgG and IgM against hypochlorite (HOCl) and malondialdehyde (MDA) oxLDL using ELISA (values in optical density). Results-Patients with CSVD had higher levels of IgG-HOCl-oxLDL (0.77 versus 0.70; P
AB - Background and Purpose-Oxidized low-density lipoprotein (oxLDL) induces endothelial dysfunction and antibody formation. Because endothelial dysfunction is involved in cerebral small vessel disease (CSVD) (dilated Virchow Robin spaces, lacunar infarcts, and white matter lesions), oxLDL antibodies could play a role in CSVD pathogenesis. Therefore, we studied oxLDL antibodies in patients with high prevalence of CSVD: lacunar stroke patients and essential hypertensive patients. Methods-A total of 158 lacunar stroke patients, 158 hypertensive patients, and 43 healthy controls were included. We determined levels of IgG and IgM against hypochlorite (HOCl) and malondialdehyde (MDA) oxLDL using ELISA (values in optical density). Results-Patients with CSVD had higher levels of IgG-HOCl-oxLDL (0.77 versus 0.70; P
KW - lacunar infarct
KW - stroke
KW - white matter lesions
KW - oxidized low-density lipoproteins
KW - hypertension
U2 - 10.1161/STROKEAHA.110.592725
DO - 10.1161/STROKEAHA.110.592725
M3 - Article
C2 - 20947847
SN - 0039-2499
VL - 41
SP - 2687
EP - 2689
JO - Stroke
JF - Stroke
IS - 11
ER -