Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease

Rob P. W. Rouhl; Robert J. van Oostenbrugge; Ruud O. M. F. I. H. Theunissen; Iris L. H. Knottnerus; Julie Staals; Leon H. G. Henskens; Abraham A. Kroon; Peter W. de Leeuw; Jan Lodder; Jan Willem Cohen Tervaert; Jan G. M. C. Damoiseaux

doi:10.1161/STROKEAHA.110.592725

Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease

Rob P. W. Rouhl^*, Robert J. van Oostenbrugge, Ruud O. M. F. I. H. Theunissen, Iris L. H. Knottnerus, Julie Staals, Leon H. G. Henskens, Abraham A. Kroon, Peter W. de Leeuw, Jan Lodder, Jan Willem Cohen Tervaert, Jan G. M. C. Damoiseaux

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Web of Science)

Abstract

Background and Purpose-Oxidized low-density lipoprotein (oxLDL) induces endothelial dysfunction and antibody formation. Because endothelial dysfunction is involved in cerebral small vessel disease (CSVD) (dilated Virchow Robin spaces, lacunar infarcts, and white matter lesions), oxLDL antibodies could play a role in CSVD pathogenesis. Therefore, we studied oxLDL antibodies in patients with high prevalence of CSVD: lacunar stroke patients and essential hypertensive patients. Methods-A total of 158 lacunar stroke patients, 158 hypertensive patients, and 43 healthy controls were included. We determined levels of IgG and IgM against hypochlorite (HOCl) and malondialdehyde (MDA) oxLDL using ELISA (values in optical density). Results-Patients with CSVD had higher levels of IgG-HOCl-oxLDL (0.77 versus 0.70; P

Original language	English
Pages (from-to)	2687-2689
Journal	Stroke
Volume	41
Issue number	11
DOIs	https://doi.org/10.1161/STROKEAHA.110.592725
Publication status	Published - Nov 2010

Keywords

lacunar infarct
stroke
white matter lesions
oxidized low-density lipoproteins
hypertension

Access to Document

10.1161/STROKEAHA.110.592725

Cite this

Rouhl, R. P. W., van Oostenbrugge, R. J., Theunissen, R. O. M. F. I. H., Knottnerus, I. L. H., Staals, J., Henskens, L. H. G., Kroon, A. A., de Leeuw, P. W., Lodder, J., Tervaert, J. W. C., & Damoiseaux, J. G. M. C. (2010). Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease. Stroke, 41(11), 2687-2689. https://doi.org/10.1161/STROKEAHA.110.592725

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title = "Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease",

abstract = "Background and Purpose-Oxidized low-density lipoprotein (oxLDL) induces endothelial dysfunction and antibody formation. Because endothelial dysfunction is involved in cerebral small vessel disease (CSVD) (dilated Virchow Robin spaces, lacunar infarcts, and white matter lesions), oxLDL antibodies could play a role in CSVD pathogenesis. Therefore, we studied oxLDL antibodies in patients with high prevalence of CSVD: lacunar stroke patients and essential hypertensive patients. Methods-A total of 158 lacunar stroke patients, 158 hypertensive patients, and 43 healthy controls were included. We determined levels of IgG and IgM against hypochlorite (HOCl) and malondialdehyde (MDA) oxLDL using ELISA (values in optical density). Results-Patients with CSVD had higher levels of IgG-HOCl-oxLDL (0.77 versus 0.70; P",

keywords = "lacunar infarct, stroke, white matter lesions, oxidized low-density lipoproteins, hypertension",

author = "Rouhl, {Rob P. W.} and {van Oostenbrugge}, {Robert J.} and Theunissen, {Ruud O. M. F. I. H.} and Knottnerus, {Iris L. H.} and Julie Staals and Henskens, {Leon H. G.} and Kroon, {Abraham A.} and {de Leeuw}, {Peter W.} and Jan Lodder and Tervaert, {Jan Willem Cohen} and Damoiseaux, {Jan G. M. C.}",

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T1 - Autoantibodies Against Oxidized Low-Density Lipoprotein in Cerebral Small Vessel Disease

AU - Rouhl, Rob P. W.

AU - van Oostenbrugge, Robert J.

AU - Theunissen, Ruud O. M. F. I. H.

AU - Knottnerus, Iris L. H.

AU - Staals, Julie

AU - Henskens, Leon H. G.

AU - Kroon, Abraham A.

AU - de Leeuw, Peter W.

AU - Lodder, Jan

AU - Tervaert, Jan Willem Cohen

AU - Damoiseaux, Jan G. M. C.

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AB - Background and Purpose-Oxidized low-density lipoprotein (oxLDL) induces endothelial dysfunction and antibody formation. Because endothelial dysfunction is involved in cerebral small vessel disease (CSVD) (dilated Virchow Robin spaces, lacunar infarcts, and white matter lesions), oxLDL antibodies could play a role in CSVD pathogenesis. Therefore, we studied oxLDL antibodies in patients with high prevalence of CSVD: lacunar stroke patients and essential hypertensive patients. Methods-A total of 158 lacunar stroke patients, 158 hypertensive patients, and 43 healthy controls were included. We determined levels of IgG and IgM against hypochlorite (HOCl) and malondialdehyde (MDA) oxLDL using ELISA (values in optical density). Results-Patients with CSVD had higher levels of IgG-HOCl-oxLDL (0.77 versus 0.70; P

KW - lacunar infarct

KW - stroke

KW - white matter lesions

KW - oxidized low-density lipoproteins

KW - hypertension

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