Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice

Ekaterina Veniaminova, Raymond Cespuglio, Chi Wai Cheung, Alexei Umriukhin, Nataliia Markova, Elena Shevtsova, Klaus-Peter Lesch, Daniel C. Anthony*, Tatyana Strekalova*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Web of Science)

Abstract

Nonalcoholic fatty liver disease, induced by a Western diet (WD), evokes central and peripheral inflammation that is accompanied by altered emotionality. These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J mice were fed with a regular chow or with a WD containing 0.2% of cholesterol and 21% of saturated fat for three weeks. WD-treated mice exhibited increased social avoidance, crawl-over and digging behaviours, decreased body-body contacts, and hyperlocomotion. The WD-fed group also displayed deficits in hippocampal-dependent performance such as contextual memory in a fear conditioning and pellet displacement paradigms. A reduction in glucose tolerance and elevated levels of serum cholesterol and leptin were also associated with the WD. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1a) mRNA, a marker of mitochondrial activity, was decreased in the prefrontal cortex, hippocampus, hypothalamus, and dorsal raphe, suggesting suppressed brain mitochondrial functions, but not in the liver. This is the first report to show that a WD can profoundly suppress social interactions and induce dominant-like behaviours in naive adult mice. The spectrum of behaviours that were found to be induced are reminiscent of symptoms associated with autism, and, if paralleled in humans, suggest that a WD might exacerbate autism spectrum disorder.

Original languageEnglish
Article number9498247
Number of pages14
JournalNeural Plasticity
Volume2017
DOIs
Publication statusPublished - 2017

Keywords

  • HIGH-FAT DIET
  • HIGH-CHOLESTEROL DIET
  • TLR4 UP-REGULATION
  • C57BL/6 MICE
  • COGNITIVE IMPAIRMENT
  • INSULIN-RESISTANCE
  • METABOLIC-SYNDROME
  • ENERGY-METABOLISM
  • SPECTRUM DISORDER
  • INDUCED OBESITY

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