Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations

Ben Alderson-Day, Kelly Diederen, Charles Fernyhough, Judith M Ford, Guillermo Horga, Daniel S Margulies, Simon McCarthy-Jones, Georg Northoff, James M Shine, Jessica Turner, Vincent van de Ven, Remko van Lutterveld, Flavie Waters, Renaud Jardri

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Abstract

In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations.

Original languageEnglish
Pages (from-to)1110-1123
Number of pages14
JournalSchizophrenia Bulletin
Volume42
Issue number5
DOIs
Publication statusPublished - Sep 2016

Cite this

Alderson-Day, B., Diederen, K., Fernyhough, C., Ford, J. M., Horga, G., Margulies, D. S., ... Jardri, R. (2016). Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations. Schizophrenia Bulletin, 42(5), 1110-1123. https://doi.org/10.1093/schbul/sbw078
Alderson-Day, Ben ; Diederen, Kelly ; Fernyhough, Charles ; Ford, Judith M ; Horga, Guillermo ; Margulies, Daniel S ; McCarthy-Jones, Simon ; Northoff, Georg ; Shine, James M ; Turner, Jessica ; van de Ven, Vincent ; van Lutterveld, Remko ; Waters, Flavie ; Jardri, Renaud. / Auditory Hallucinations and the Brain's Resting-State Networks : Findings and Methodological Observations. In: Schizophrenia Bulletin. 2016 ; Vol. 42, No. 5. pp. 1110-1123.
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Alderson-Day, B, Diederen, K, Fernyhough, C, Ford, JM, Horga, G, Margulies, DS, McCarthy-Jones, S, Northoff, G, Shine, JM, Turner, J, van de Ven, V, van Lutterveld, R, Waters, F & Jardri, R 2016, 'Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations', Schizophrenia Bulletin, vol. 42, no. 5, pp. 1110-1123. https://doi.org/10.1093/schbul/sbw078

Auditory Hallucinations and the Brain's Resting-State Networks : Findings and Methodological Observations. / Alderson-Day, Ben; Diederen, Kelly; Fernyhough, Charles; Ford, Judith M; Horga, Guillermo; Margulies, Daniel S; McCarthy-Jones, Simon; Northoff, Georg; Shine, James M; Turner, Jessica; van de Ven, Vincent; van Lutterveld, Remko; Waters, Flavie; Jardri, Renaud.

In: Schizophrenia Bulletin, Vol. 42, No. 5, 09.2016, p. 1110-1123.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Fernyhough, Charles

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AU - Horga, Guillermo

AU - Margulies, Daniel S

AU - McCarthy-Jones, Simon

AU - Northoff, Georg

AU - Shine, James M

AU - Turner, Jessica

AU - van de Ven, Vincent

AU - van Lutterveld, Remko

AU - Waters, Flavie

AU - Jardri, Renaud

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AB - In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations.

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Alderson-Day B, Diederen K, Fernyhough C, Ford JM, Horga G, Margulies DS et al. Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations. Schizophrenia Bulletin. 2016 Sep;42(5):1110-1123. https://doi.org/10.1093/schbul/sbw078