Audiovisual association learning in the absence of primary visual cortex

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Learning audiovisual associations is mediated by the primary cortical areas; however, recent animal studies suggest that such learning can take place even in the absence of the primary visual cortex. Other studies have demonstrated the involvement of extra-geniculate pathways and especially the superior colliculus (SC) in audiovisual association learning. Here, we investigated such learning in a rare human patient with complete loss of the bilateral striate cortex. We carried out an implicit audiovisual association learning task with two different colors of red and purple (the latter color known to minimally activate the extra-genicular pathway). Interestingly, the patient learned the association between an auditory cue and a visual stimulus only when the unseen visual stimulus was red, but not when it was purple. The current study presents the first evidence showing the possibility of audiovisual association learning in humans with lesioned striate cortex. Furthermore, in line with animal studies, it supports an important role for the SC in audiovisual associative learning.
Original languageEnglish
Article number686
Number of pages6
JournalFrontiers in Human Neuroscience
Volume9
DOIs
Publication statusPublished - 5 Jan 2016

Keywords

  • audiovisual learning
  • superior colliculus
  • blindsight
  • SUPERIOR COLLICULUS
  • MULTISENSORY INTEGRATION
  • STRIATE CORTEX
  • BLINDSIGHT
  • VISION
  • AMYGDALA
  • MONKEY
  • CELLS

Cite this

@article{8482e7a6d81544289a7a15928c738b9e,
title = "Audiovisual association learning in the absence of primary visual cortex",
abstract = "Learning audiovisual associations is mediated by the primary cortical areas; however, recent animal studies suggest that such learning can take place even in the absence of the primary visual cortex. Other studies have demonstrated the involvement of extra-geniculate pathways and especially the superior colliculus (SC) in audiovisual association learning. Here, we investigated such learning in a rare human patient with complete loss of the bilateral striate cortex. We carried out an implicit audiovisual association learning task with two different colors of red and purple (the latter color known to minimally activate the extra-genicular pathway). Interestingly, the patient learned the association between an auditory cue and a visual stimulus only when the unseen visual stimulus was red, but not when it was purple. The current study presents the first evidence showing the possibility of audiovisual association learning in humans with lesioned striate cortex. Furthermore, in line with animal studies, it supports an important role for the SC in audiovisual associative learning.",
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author = "M. Seirafi and {de Weerd}, P. and A.J. Pegna and {de Gelder}, B.",
year = "2016",
month = "1",
day = "5",
doi = "10.3389/fnhum.2015.00686",
language = "English",
volume = "9",
journal = "Frontiers in Human Neuroscience",
issn = "1662-5161",
publisher = "Frontiers Media S.A.",

}

Audiovisual association learning in the absence of primary visual cortex. / Seirafi, M.; de Weerd, P.; Pegna, A.J.; de Gelder, B.

In: Frontiers in Human Neuroscience, Vol. 9, 686, 05.01.2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Audiovisual association learning in the absence of primary visual cortex

AU - Seirafi, M.

AU - de Weerd, P.

AU - Pegna, A.J.

AU - de Gelder, B.

PY - 2016/1/5

Y1 - 2016/1/5

N2 - Learning audiovisual associations is mediated by the primary cortical areas; however, recent animal studies suggest that such learning can take place even in the absence of the primary visual cortex. Other studies have demonstrated the involvement of extra-geniculate pathways and especially the superior colliculus (SC) in audiovisual association learning. Here, we investigated such learning in a rare human patient with complete loss of the bilateral striate cortex. We carried out an implicit audiovisual association learning task with two different colors of red and purple (the latter color known to minimally activate the extra-genicular pathway). Interestingly, the patient learned the association between an auditory cue and a visual stimulus only when the unseen visual stimulus was red, but not when it was purple. The current study presents the first evidence showing the possibility of audiovisual association learning in humans with lesioned striate cortex. Furthermore, in line with animal studies, it supports an important role for the SC in audiovisual associative learning.

AB - Learning audiovisual associations is mediated by the primary cortical areas; however, recent animal studies suggest that such learning can take place even in the absence of the primary visual cortex. Other studies have demonstrated the involvement of extra-geniculate pathways and especially the superior colliculus (SC) in audiovisual association learning. Here, we investigated such learning in a rare human patient with complete loss of the bilateral striate cortex. We carried out an implicit audiovisual association learning task with two different colors of red and purple (the latter color known to minimally activate the extra-genicular pathway). Interestingly, the patient learned the association between an auditory cue and a visual stimulus only when the unseen visual stimulus was red, but not when it was purple. The current study presents the first evidence showing the possibility of audiovisual association learning in humans with lesioned striate cortex. Furthermore, in line with animal studies, it supports an important role for the SC in audiovisual associative learning.

KW - audiovisual learning

KW - superior colliculus

KW - blindsight

KW - SUPERIOR COLLICULUS

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KW - STRIATE CORTEX

KW - BLINDSIGHT

KW - VISION

KW - AMYGDALA

KW - MONKEY

KW - CELLS

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