Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis

Deborah Carper, Marine Coue, Emmani B. M. Nascimento, Valentin Barquissau, Damien Lagarde, Carine Pestourie, Claire Laurens, Justine Vily Petit, Maud Soty, Laurent Monbrun, Marie-Adeline Marques, Yannick Jeanson, Yannis Sainte-Marie, Aline Mairal, Sebastien Dejean, Genevieve Tavernier, Nathalie Viguerie, Virginie Bourlier, Frank Lezoualc'h, Audrey CarriereWim H. M. Saris, Arne Astrup, Louis Casteilla, Gilles Mithieux, W. D. van Marken Lichtenbelt, Dominique Langin, Patrick Schrauwen, Cedric Moro*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Web of Science)

Abstract

Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and pressure in mammals. It is still unclear whether ANP controls cold-induced thermogenesis in vivo. Here, we show that acute cold exposure induces cardiac ANP secretion in mice and humans. Genetic inactivation of ANP promotes cold intolerance and suppresses half of cold-induced brown adipose tissue (BAT) activation in mice. While white adipocytes are resistant to ANP-mediated lipolysis at thermoneutral temperature in mice, cold exposure renders white adipocytes fully responsive to ANP to activate lipolysis and a thermogenic program, a physiological response that is dramatically suppressed in ANP null mice. ANP deficiency also blunts liver triglycerides and glycogen metabolism, thus impairing fuel availability for BAT thermogenesis. ANP directly increases mitochondrial uncoupling and thermogenic gene expression in human white and brown adipocytes. Together, these results indicate that ANP is a major physiological trigger of BAT thermogenesis upon cold exposure in mammals.

Original languageEnglish
Article number108075
Number of pages19
JournalCell Reports
Volume32
Issue number8
DOIs
Publication statusPublished - 25 Aug 2020

Keywords

  • BROWN ADIPOSE-TISSUE
  • COLD-INDUCED THERMOGENESIS
  • ACTIVATED PROTEIN-KINASE
  • INSULIN-RESISTANCE
  • BEIGE ADIPOCYTES
  • WEIGHT-LOSS
  • RECEPTOR
  • OBESITY
  • INDUCE
  • IDENTIFICATION

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