Atherosclerosis: current pathogenesis and therapeutic options

Christian Weber*, Heidi Noels

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1400 Citations (Web of Science)

Abstract

Coronary artery disease (CAD) arising from atherosclerosis is a leading cause of death and morbidity worldwide. The underlying pathogenesis involves an imbalanced lipid metabolism and a maladaptive immune response entailing a chronic inflammation of the arterial wall. The disturbed equilibrium of lipid accumulation, immune responses and their clearance is shaped by leukocyte trafficking and homeostasis governed by chemokines and their receptors. New pro- and anti-inflammatory pathways linking lipid and inflammation biology have been discovered, and genetic profiling studies have unveiled variations involved in human CAD. The growing understanding of the inflammatory processes and mediators has uncovered an intriguing diversity of targetable mechanisms that can be exploited to complement lipid-lowering therapies. Here we aim to systematically survey recently identified molecular mechanisms, translational developments and clinical strategies for targeting lipid-related inflammation in atherosclerosis and CAD.
Original languageEnglish
Pages (from-to)1410-1422
JournalNature Medicine
Volume17
Issue number11
DOIs
Publication statusPublished - Nov 2011

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