AT2 receptors in cardiovascular and renal diseases

Elena Kaschina, Pawel Namsolleck, Thomas Unger*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

58 Citations (Web of Science)

Abstract

The renin-angiotensin system (RAS) plays an important role in the initiation and progression of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are well established and led to development of selective AT1R blockers (ARB5). In contrast, there is scientific evidence that AT2 receptor (AT2R) mediates effects different from and often opposing those of the AT1R. Meagrely expressed in healthy tissue the AT2R is upregulated in injuries providing an endogenous protection to inflammatory, oxidative and apoptotic processes. Interestingly the beneficial effects mediated by AT2R can be further enhanced by pharmacological intervention using the recently developed AT2R agonists. This review article summarizes our current knowledge about regulation, signalling and effects mediated by AT2R in health and disease, with emphasis on cardiac and renal systems. At the end a novel concept of natural protective systems will be introduced and discussed as an attractive target in drug development. (C) 2017 Published by Elsevier Ltd.

Original languageEnglish
Pages (from-to)39-47
Number of pages9
JournalPharmacological Research
Volume125
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Renin-angiotensin system (RAS)
  • Angiotensin AT2 receptor (AT2R)
  • Myocardial infarction (MI)
  • Chronic kidney disease (CKD)
  • Natural protective system
  • II TYPE-2 RECEPTOR
  • ANGIOTENSIN AT(2) RECEPTOR
  • OBESE ZUCKER RATS
  • CONVERTING ENZYME-INHIBITORS
  • LEFT-VENTRICULAR HYPERTROPHY
  • ACUTE MYOCARDIAL-INFARCTION
  • COMPOUND 21
  • POSTMYOCARDIAL INFARCTION
  • DIABETIC-NEPHROPATHY
  • HEART-FAILURE

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