AT(2) Receptor and Tissue Injury: Therapeutic Implications

Pawel Namsolleck, Chiara Recarti, Sebastien Foulquier, Ulrike Muscha Steckelings, Thomas Unger*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

67 Citations (Web of Science)

Abstract

The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT(1) receptor (AT(1)R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty years, protective actions of the RAS, not only in the cardiovascular, but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT(2)-receptors and Mas receptors (AT(2)R and MasR) and is characterized by effects different from and often opposing those of the AT(1)R. These include anti-inflammation, anti-fibrosis, anti-apoptosis and neuroregeneration that can counterbalance pathological processes and enable recovery from disease. The recent development of novel, small-molecule AT(2)R agonists offers a therapeutic potential in humans with a variety of clinical indications.
Original languageEnglish
Article number416
JournalCurrent Hypertension Reports
Volume16
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Renin-angiotensin system
  • AT(2) receptor
  • Angiotensin II
  • CGP42112
  • PD123319
  • Signaling
  • Tissue injury
  • Inflammation
  • Fibrosis
  • Apoptosis
  • Growth promotion/inhibition
  • Cardioprotection
  • Vascular protection
  • Neuroprotection
  • Neuroregeneration
  • Myocardial infarction
  • Aortic aneurysm
  • Atherosclerosis
  • Hypertension
  • Stroke
  • Spinal cord injury

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