Astaxanthin supplementation does not augment fat use or improve endurance performance.

P.T. Res, N.M. Cermak, R.E. Stinkens, T. J. Tollakson, G.R.M.M. Haenen, A. Bast, L.J.C. van Loon

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

INTRODUCTION: Astaxanthin is a lipid-soluble carotenoid found in a variety of aquatic organisms. Prolonged astaxanthin supplementation has been reported to increase fat oxidative capacity and improve running time to exhaustion in mice. These data suggest that astaxanthin may be applied as a potent ergogenic aid in humans. PURPOSE: To assess the impact of 4 wks astaxanthin supplementation on substrate use and subsequent time trial performance in well-trained cyclists. METHODS: Using a double-blind parallel design, 32 young, well-trained male cyclists or triathletes (age: 25+/-1 y, weight: 73+/-1 kg, VO2peak: 60+/-1 mL.kg.min, Wmax: 395+/-7 W) were supplemented for 4 wks with 20 mg astaxanthin per day (ASTA) or a placebo (PLA). Before and after the supplementation period, subjects performed 60 min of exercise (50% Wmax), followed by a ~1 h time trial. RESULTS: Daily astaxanthin supplementation significantly increased basal plasma astaxanthin concentrations from non-detectable values to 187+/-19 mug.kg (P<0.05). This elevation was not reflected in greater total plasma anti-oxidant capacity (P=0.90) or attenuated malondialdehyde levels (P=0.63). Whole-body fat oxidation rates during submaximal exercise did not differ between groups and did not change over time (from 0.71+/-0.04 to 0.68+/-0.03 g.min and 0.66+/-0.04 to 0.61+/-0.05 g.min in the PLA and ASTA group, respectively; P=0.73). No improvements in time trial performance were observed in either group (from 236+/-9 to 239+/-7 and from 238+/-6 to 244+/-6 W in the PLA and ASTA group, respectively; P=0.63). CONCLUSIONS: Prolonged astaxanthin supplementation does not augment anti-oxidant capacity, increase fat oxidative capacity, or improve time trial performance in trained cyclists.
Original languageEnglish
Pages (from-to)1158-1165
Number of pages8
JournalMedicine and Science in Sports and Exercise
Volume45
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • SUBSTRATE USE
  • CYCLING
  • FAT OXIDATION
  • EXERCISE
  • ERGOGENIC AIDS
  • ANTI-OXIDANTS
  • TIME-TRIAL PERFORMANCE
  • OXIDATIVE STRESS
  • ANTIOXIDANT ASTAXANTHIN
  • UP-REGULATION
  • CPT-I
  • MICE
  • DAMAGE
  • DIET
  • CAROTENOIDS

Cite this

@article{02965ae68b7c43b0af8631ea44260e7a,
title = "Astaxanthin supplementation does not augment fat use or improve endurance performance.",
abstract = "INTRODUCTION: Astaxanthin is a lipid-soluble carotenoid found in a variety of aquatic organisms. Prolonged astaxanthin supplementation has been reported to increase fat oxidative capacity and improve running time to exhaustion in mice. These data suggest that astaxanthin may be applied as a potent ergogenic aid in humans. PURPOSE: To assess the impact of 4 wks astaxanthin supplementation on substrate use and subsequent time trial performance in well-trained cyclists. METHODS: Using a double-blind parallel design, 32 young, well-trained male cyclists or triathletes (age: 25+/-1 y, weight: 73+/-1 kg, VO2peak: 60+/-1 mL.kg.min, Wmax: 395+/-7 W) were supplemented for 4 wks with 20 mg astaxanthin per day (ASTA) or a placebo (PLA). Before and after the supplementation period, subjects performed 60 min of exercise (50{\%} Wmax), followed by a ~1 h time trial. RESULTS: Daily astaxanthin supplementation significantly increased basal plasma astaxanthin concentrations from non-detectable values to 187+/-19 mug.kg (P<0.05). This elevation was not reflected in greater total plasma anti-oxidant capacity (P=0.90) or attenuated malondialdehyde levels (P=0.63). Whole-body fat oxidation rates during submaximal exercise did not differ between groups and did not change over time (from 0.71+/-0.04 to 0.68+/-0.03 g.min and 0.66+/-0.04 to 0.61+/-0.05 g.min in the PLA and ASTA group, respectively; P=0.73). No improvements in time trial performance were observed in either group (from 236+/-9 to 239+/-7 and from 238+/-6 to 244+/-6 W in the PLA and ASTA group, respectively; P=0.63). CONCLUSIONS: Prolonged astaxanthin supplementation does not augment anti-oxidant capacity, increase fat oxidative capacity, or improve time trial performance in trained cyclists.",
keywords = "SUBSTRATE USE, CYCLING, FAT OXIDATION, EXERCISE, ERGOGENIC AIDS, ANTI-OXIDANTS, TIME-TRIAL PERFORMANCE, OXIDATIVE STRESS, ANTIOXIDANT ASTAXANTHIN, UP-REGULATION, CPT-I, MICE, DAMAGE, DIET, CAROTENOIDS",
author = "P.T. Res and N.M. Cermak and R.E. Stinkens and Tollakson, {T. J.} and G.R.M.M. Haenen and A. Bast and {van Loon}, L.J.C.",
year = "2013",
month = "6",
doi = "10.1249/MSS.0b013e31827fddc4",
language = "English",
volume = "45",
pages = "1158--1165",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "6",

}

Astaxanthin supplementation does not augment fat use or improve endurance performance. / Res, P.T.; Cermak, N.M.; Stinkens, R.E.; Tollakson, T. J.; Haenen, G.R.M.M.; Bast, A.; van Loon, L.J.C.

In: Medicine and Science in Sports and Exercise, Vol. 45, No. 6, 06.2013, p. 1158-1165.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Astaxanthin supplementation does not augment fat use or improve endurance performance.

AU - Res, P.T.

AU - Cermak, N.M.

AU - Stinkens, R.E.

AU - Tollakson, T. J.

AU - Haenen, G.R.M.M.

AU - Bast, A.

AU - van Loon, L.J.C.

PY - 2013/6

Y1 - 2013/6

N2 - INTRODUCTION: Astaxanthin is a lipid-soluble carotenoid found in a variety of aquatic organisms. Prolonged astaxanthin supplementation has been reported to increase fat oxidative capacity and improve running time to exhaustion in mice. These data suggest that astaxanthin may be applied as a potent ergogenic aid in humans. PURPOSE: To assess the impact of 4 wks astaxanthin supplementation on substrate use and subsequent time trial performance in well-trained cyclists. METHODS: Using a double-blind parallel design, 32 young, well-trained male cyclists or triathletes (age: 25+/-1 y, weight: 73+/-1 kg, VO2peak: 60+/-1 mL.kg.min, Wmax: 395+/-7 W) were supplemented for 4 wks with 20 mg astaxanthin per day (ASTA) or a placebo (PLA). Before and after the supplementation period, subjects performed 60 min of exercise (50% Wmax), followed by a ~1 h time trial. RESULTS: Daily astaxanthin supplementation significantly increased basal plasma astaxanthin concentrations from non-detectable values to 187+/-19 mug.kg (P<0.05). This elevation was not reflected in greater total plasma anti-oxidant capacity (P=0.90) or attenuated malondialdehyde levels (P=0.63). Whole-body fat oxidation rates during submaximal exercise did not differ between groups and did not change over time (from 0.71+/-0.04 to 0.68+/-0.03 g.min and 0.66+/-0.04 to 0.61+/-0.05 g.min in the PLA and ASTA group, respectively; P=0.73). No improvements in time trial performance were observed in either group (from 236+/-9 to 239+/-7 and from 238+/-6 to 244+/-6 W in the PLA and ASTA group, respectively; P=0.63). CONCLUSIONS: Prolonged astaxanthin supplementation does not augment anti-oxidant capacity, increase fat oxidative capacity, or improve time trial performance in trained cyclists.

AB - INTRODUCTION: Astaxanthin is a lipid-soluble carotenoid found in a variety of aquatic organisms. Prolonged astaxanthin supplementation has been reported to increase fat oxidative capacity and improve running time to exhaustion in mice. These data suggest that astaxanthin may be applied as a potent ergogenic aid in humans. PURPOSE: To assess the impact of 4 wks astaxanthin supplementation on substrate use and subsequent time trial performance in well-trained cyclists. METHODS: Using a double-blind parallel design, 32 young, well-trained male cyclists or triathletes (age: 25+/-1 y, weight: 73+/-1 kg, VO2peak: 60+/-1 mL.kg.min, Wmax: 395+/-7 W) were supplemented for 4 wks with 20 mg astaxanthin per day (ASTA) or a placebo (PLA). Before and after the supplementation period, subjects performed 60 min of exercise (50% Wmax), followed by a ~1 h time trial. RESULTS: Daily astaxanthin supplementation significantly increased basal plasma astaxanthin concentrations from non-detectable values to 187+/-19 mug.kg (P<0.05). This elevation was not reflected in greater total plasma anti-oxidant capacity (P=0.90) or attenuated malondialdehyde levels (P=0.63). Whole-body fat oxidation rates during submaximal exercise did not differ between groups and did not change over time (from 0.71+/-0.04 to 0.68+/-0.03 g.min and 0.66+/-0.04 to 0.61+/-0.05 g.min in the PLA and ASTA group, respectively; P=0.73). No improvements in time trial performance were observed in either group (from 236+/-9 to 239+/-7 and from 238+/-6 to 244+/-6 W in the PLA and ASTA group, respectively; P=0.63). CONCLUSIONS: Prolonged astaxanthin supplementation does not augment anti-oxidant capacity, increase fat oxidative capacity, or improve time trial performance in trained cyclists.

KW - SUBSTRATE USE

KW - CYCLING

KW - FAT OXIDATION

KW - EXERCISE

KW - ERGOGENIC AIDS

KW - ANTI-OXIDANTS

KW - TIME-TRIAL PERFORMANCE

KW - OXIDATIVE STRESS

KW - ANTIOXIDANT ASTAXANTHIN

KW - UP-REGULATION

KW - CPT-I

KW - MICE

KW - DAMAGE

KW - DIET

KW - CAROTENOIDS

U2 - 10.1249/MSS.0b013e31827fddc4

DO - 10.1249/MSS.0b013e31827fddc4

M3 - Article

VL - 45

SP - 1158

EP - 1165

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 6

ER -