TY - JOUR
T1 - Associations of the dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations with patient-reported outcomes in colorectal cancer survivors 2-10 years post-diagnosis: a cross-sectional analysis
AU - Kenkhuis, M.F.
AU - van der Linden, B.W.A.
AU - Breedveld-Peters, J.J.L.
AU - Koole, J.L.
AU - van Roekel, E.H.
AU - Breukink, S.O.
AU - Mols, F.
AU - Weijenberg, M.P.
AU - Bours, M.J.L.
PY - 2021/5/28
Y1 - 2021/5/28
N2 - The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Adhering to these recommendations may have beneficial effects on patient-reported outcomes after a cancer diagnosis, but evidence is scarce. We aimed to assess associations of the individual dietary WCRF/AICR recommendations regarding fruit and vegetables, fibre, fast foods, red and processed meat, sugar-sweetened drinks and alcohol consumption with patient-reported outcomes in colorectal cancer (CRC) survivors. Cross-sectional data of 150 stage I-III CRC survivors, 2-10 years post-diagnosis, were used. Dietary intake was measured by 7-d dietary records. Validated questionnaires were used to measure health-related quality of life (HRQoL), fatigue and neuropathy. Confounder-adjusted linear regression models were used to analyse associations of each WCRF/AICR dietary recommendation with patient-reported outcomes. Higher vegetable intake (per 50 g) was associated with better global QoL (beta 2 center dot 6; 95 % CI 0 center dot 6, 4 center dot 7), better physical functioning (3 center dot 3; 1 center dot 2, 5 center dot 5) and lower levels of fatigue (-4 center dot 5; -7 center dot 6, -1 center dot 4). Higher fruit and vegetables intake (per 100 g) was associated with better physical functioning (3 center dot 2; 0 center dot 8, 5 center dot 5) and higher intake of energy-dense food (per 100 kJ/100 g) with worse physical functioning (-4 center dot 2; -7 center dot 1, -1 center dot 2). No associations of dietary recommendations with neuropathy were found. These findings suggest that adhering to specific dietary WCRF/AICR recommendations is associated with better HRQoL and less fatigue in CRC survivors. Although the recommendations regarding healthy dietary habits may be beneficial for the well-being of CRC survivors, longitudinal research is warranted to gain insight into the direction of associations.
AB - The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention. Adhering to these recommendations may have beneficial effects on patient-reported outcomes after a cancer diagnosis, but evidence is scarce. We aimed to assess associations of the individual dietary WCRF/AICR recommendations regarding fruit and vegetables, fibre, fast foods, red and processed meat, sugar-sweetened drinks and alcohol consumption with patient-reported outcomes in colorectal cancer (CRC) survivors. Cross-sectional data of 150 stage I-III CRC survivors, 2-10 years post-diagnosis, were used. Dietary intake was measured by 7-d dietary records. Validated questionnaires were used to measure health-related quality of life (HRQoL), fatigue and neuropathy. Confounder-adjusted linear regression models were used to analyse associations of each WCRF/AICR dietary recommendation with patient-reported outcomes. Higher vegetable intake (per 50 g) was associated with better global QoL (beta 2 center dot 6; 95 % CI 0 center dot 6, 4 center dot 7), better physical functioning (3 center dot 3; 1 center dot 2, 5 center dot 5) and lower levels of fatigue (-4 center dot 5; -7 center dot 6, -1 center dot 4). Higher fruit and vegetables intake (per 100 g) was associated with better physical functioning (3 center dot 2; 0 center dot 8, 5 center dot 5) and higher intake of energy-dense food (per 100 kJ/100 g) with worse physical functioning (-4 center dot 2; -7 center dot 1, -1 center dot 2). No associations of dietary recommendations with neuropathy were found. These findings suggest that adhering to specific dietary WCRF/AICR recommendations is associated with better HRQoL and less fatigue in CRC survivors. Although the recommendations regarding healthy dietary habits may be beneficial for the well-being of CRC survivors, longitudinal research is warranted to gain insight into the direction of associations.
KW - Colorectal cancer survivorship
KW - Lifestyle recommendations
KW - Diet
KW - Health-related quality of life
KW - Fatigue
KW - Neuropathy
KW - QUALITY-OF-LIFE
KW - INDUCED PERIPHERAL NEUROPATHY
KW - BODY-MASS INDEX
KW - PHYSICAL-ACTIVITY
KW - MEDITERRANEAN DIET
KW - STYLE FACTORS
KW - VEGETABLE INTAKE
KW - COLON-CANCER
KW - HEALTH
KW - CHEMOTHERAPY
U2 - 10.1017/S0007114520003487
DO - 10.1017/S0007114520003487
M3 - Article
C2 - 33087189
SN - 0007-1145
VL - 125
SP - 1188
EP - 1200
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 10
M1 - 0007114520003487
ER -