Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study

Pauline B. C. Linssen; Marja G. J. Veugen; Ronald M. A. Henry; Carla J. H. van Der Kallen; Abraham A. Kroon; Miranda T. Schram; Hans-Peter Brunner-La Rocca; Coen D. A. Stehouwer

doi:10.1186/s12933-020-01055-y

Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study

Pauline B. C. Linssen, Marja G. J. Veugen, Ronald M. A. Henry, Carla J. H. van Der Kallen, Abraham A. Kroon, Miranda T. Schram, Hans-Peter Brunner-La Rocca, Coen D. A. Stehouwer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BackgroundsThe role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the associations between (pre)diabetes and RV and RA structure and function, and whether these are mediated by left ventricular (LV) alterations or pulmonary pressure.MethodsParticipants of the Maastricht Study; a population-based cohort study (426 normal glucose metabolism (NGM), 142 prediabetes, 224 diabetes), underwent two-dimensional and tissue Doppler echocardiography. Multiple linear regression analyses with pairwise comparisons of (pre)diabetes versus NGM, adjusted for cardiovascular risk factors, and mediation analyses were used.ResultsIn general, differences were small. Nevertheless, in individuals with prediabetes and diabetes compared to NGM; RA volume index was lower (both pRV was lower (p=0.01 and p=0.02 respectively, p(trend)=0.01) and TDI A ' RV was lower (p

Original language	English
Article number	88
Number of pages	12
Journal	Cardiovascular Diabetology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12933-020-01055-y
Publication status	Published - 15 Jun 2020

Keywords

Heart failure
Echocardiography
Right atrial and ventricular structure
Right ventricular function
(pre)diabetes
GLOMERULAR-FILTRATION-RATE
TYPE-2 DIABETES-MELLITUS
RIGHT HEART MECHANICS
CARDIOVASCULAR-DISEASE
EUROPEAN ASSOCIATION
METABOLIC SYNDROME
AMERICAN SOCIETY
DYSFUNCTION
FAILURE
ADULTS

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Cite this

@article{87aeca99fc80442b961108a8deba7a2b,

title = "Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study",

abstract = "BackgroundsThe role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the associations between (pre)diabetes and RV and RA structure and function, and whether these are mediated by left ventricular (LV) alterations or pulmonary pressure.MethodsParticipants of the Maastricht Study; a population-based cohort study (426 normal glucose metabolism (NGM), 142 prediabetes, 224 diabetes), underwent two-dimensional and tissue Doppler echocardiography. Multiple linear regression analyses with pairwise comparisons of (pre)diabetes versus NGM, adjusted for cardiovascular risk factors, and mediation analyses were used.ResultsIn general, differences were small. Nevertheless, in individuals with prediabetes and diabetes compared to NGM; RA volume index was lower (both pRV was lower (p=0.01 and p=0.02 respectively, p(trend)=0.01) and TDI A ' RV was lower (p",

keywords = "Heart failure, Echocardiography, Right atrial and ventricular structure, Right ventricular function, (pre)diabetes, GLOMERULAR-FILTRATION-RATE, TYPE-2 DIABETES-MELLITUS, RIGHT HEART MECHANICS, CARDIOVASCULAR-DISEASE, EUROPEAN ASSOCIATION, METABOLIC SYNDROME, AMERICAN SOCIETY, DYSFUNCTION, FAILURE, ADULTS",

author = "Linssen, {Pauline B. C.} and Veugen, {Marja G. J.} and Henry, {Ronald M. A.} and {van Der Kallen}, {Carla J. H.} and Kroon, {Abraham A.} and Schram, {Miranda T.} and {Brunner-La Rocca}, Hans-Peter and Stehouwer, {Coen D. A.}",

year = "2020",

month = jun,

day = "15",

doi = "10.1186/s12933-020-01055-y",

language = "English",

volume = "19",

journal = "Cardiovascular Diabetology",

issn = "1475-2840",

publisher = "BioMed Central Ltd",

number = "1",

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TY - JOUR

T1 - Associations of (pre)diabetes with right ventricular and atrial structure and function

T2 - the Maastricht Study

AU - Linssen, Pauline B. C.

AU - Veugen, Marja G. J.

AU - Henry, Ronald M. A.

AU - van Der Kallen, Carla J. H.

AU - Kroon, Abraham A.

AU - Schram, Miranda T.

AU - Brunner-La Rocca, Hans-Peter

AU - Stehouwer, Coen D. A.

PY - 2020/6/15

Y1 - 2020/6/15

N2 - BackgroundsThe role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the associations between (pre)diabetes and RV and RA structure and function, and whether these are mediated by left ventricular (LV) alterations or pulmonary pressure.MethodsParticipants of the Maastricht Study; a population-based cohort study (426 normal glucose metabolism (NGM), 142 prediabetes, 224 diabetes), underwent two-dimensional and tissue Doppler echocardiography. Multiple linear regression analyses with pairwise comparisons of (pre)diabetes versus NGM, adjusted for cardiovascular risk factors, and mediation analyses were used.ResultsIn general, differences were small. Nevertheless, in individuals with prediabetes and diabetes compared to NGM; RA volume index was lower (both pRV was lower (p=0.01 and p=0.02 respectively, p(trend)=0.01) and TDI A ' RV was lower (p

AB - BackgroundsThe role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the associations between (pre)diabetes and RV and RA structure and function, and whether these are mediated by left ventricular (LV) alterations or pulmonary pressure.MethodsParticipants of the Maastricht Study; a population-based cohort study (426 normal glucose metabolism (NGM), 142 prediabetes, 224 diabetes), underwent two-dimensional and tissue Doppler echocardiography. Multiple linear regression analyses with pairwise comparisons of (pre)diabetes versus NGM, adjusted for cardiovascular risk factors, and mediation analyses were used.ResultsIn general, differences were small. Nevertheless, in individuals with prediabetes and diabetes compared to NGM; RA volume index was lower (both pRV was lower (p=0.01 and p=0.02 respectively, p(trend)=0.01) and TDI A ' RV was lower (p

KW - Heart failure

KW - Echocardiography

KW - Right atrial and ventricular structure

KW - Right ventricular function

KW - (pre)diabetes

KW - GLOMERULAR-FILTRATION-RATE

KW - TYPE-2 DIABETES-MELLITUS

KW - RIGHT HEART MECHANICS

KW - CARDIOVASCULAR-DISEASE

KW - EUROPEAN ASSOCIATION

KW - METABOLIC SYNDROME

KW - AMERICAN SOCIETY

KW - DYSFUNCTION

KW - FAILURE

KW - ADULTS

U2 - 10.1186/s12933-020-01055-y

DO - 10.1186/s12933-020-01055-y

M3 - Article

C2 - 32539792

SN - 1475-2840

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JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

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