Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years

Nienke Legdeur; Betty M Tijms; Elles Konijnenberg; Anouk den Braber; Mara Ten Kate; Carole H Sudre; Jori Tomassen; Maryam Badissi; Maqsood Yaqub; Frederik Barkhof; Bart N van Berckel; Dorret I Boomsma; Philip Scheltens; Henne Holstege; Andrea B Maier; Pieter Jelle Visser

doi:10.1093/gerona/glz180

Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years

Nienke Legdeur^*, Betty M Tijms, Elles Konijnenberg, Anouk den Braber, Mara Ten Kate, Carole H Sudre, Jori Tomassen, Maryam Badissi, Maqsood Yaqub, Frederik Barkhof, Bart N van Berckel, Dorret I Boomsma, Philip Scheltens, Henne Holstege, Andrea B Maier, Pieter Jelle Visser

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.

Original language	English
Pages (from-to)	1609-1617
Number of pages	9
Journal	Journals of Gerontology Series A-Biological Sciences and Medical Sciences
Volume	75
Issue number	9
Early online date	14 Aug 2019
DOIs	https://doi.org/10.1093/gerona/glz180
Publication status	Published - 1 Sept 2020

Keywords

Biomarkers
Brain aging
Cognitive function
Human aging
ALZHEIMERS-DISEASE
TEMPORAL RELATIONSHIP
HANDGRIP STRENGTH
MUSCLE STRENGTH
APOE EPSILON-4
OLDER-ADULTS
SEX
DEMENTIA
PERFORMANCE
PREVALENCE

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Legdeur, N., Tijms, B. M., Konijnenberg, E., den Braber, A., Ten Kate, M., Sudre, C. H., Tomassen, J., Badissi, M., Yaqub, M., Barkhof, F., van Berckel, B. N., Boomsma, D. I., Scheltens, P., Holstege, H., Maier, A. B., & Visser, P. J. (2020). Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 75(9), 1609-1617. https://doi.org/10.1093/gerona/glz180

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title = "Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years",

abstract = "The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.",

keywords = "Biomarkers, Brain aging, Cognitive function, Human aging, ALZHEIMERS-DISEASE, TEMPORAL RELATIONSHIP, HANDGRIP STRENGTH, MUSCLE STRENGTH, APOE EPSILON-4, OLDER-ADULTS, SEX, DEMENTIA, PERFORMANCE, PREVALENCE",

author = "Nienke Legdeur and Tijms, {Betty M} and Elles Konijnenberg and {den Braber}, Anouk and {Ten Kate}, Mara and Sudre, {Carole H} and Jori Tomassen and Maryam Badissi and Maqsood Yaqub and Frederik Barkhof and {van Berckel}, {Bart N} and Boomsma, {Dorret I} and Philip Scheltens and Henne Holstege and Maier, {Andrea B} and Visser, {Pieter Jelle}",

note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: [email protected].",

year = "2020",

month = sep,

day = "1",

doi = "10.1093/gerona/glz180",

language = "English",

volume = "75",

pages = "1609--1617",

journal = "Journals of Gerontology Series A-Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "9",

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Legdeur, N, Tijms, BM, Konijnenberg, E, den Braber, A, Ten Kate, M, Sudre, CH, Tomassen, J, Badissi, M, Yaqub, M, Barkhof, F, van Berckel, BN, Boomsma, DI, Scheltens, P, Holstege, H, Maier, AB & Visser, PJ 2020, 'Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years', Journals of Gerontology Series A-Biological Sciences and Medical Sciences, vol. 75, no. 9, pp. 1609-1617. https://doi.org/10.1093/gerona/glz180

Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years. / Legdeur, Nienke; Tijms, Betty M; Konijnenberg, Elles et al.
In: Journals of Gerontology Series A-Biological Sciences and Medical Sciences, Vol. 75, No. 9, 01.09.2020, p. 1609-1617.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years

AU - Legdeur, Nienke

AU - Tijms, Betty M

AU - Konijnenberg, Elles

AU - den Braber, Anouk

AU - Ten Kate, Mara

AU - Sudre, Carole H

AU - Tomassen, Jori

AU - Badissi, Maryam

AU - Yaqub, Maqsood

AU - Barkhof, Frederik

AU - van Berckel, Bart N

AU - Boomsma, Dorret I

AU - Scheltens, Philip

AU - Holstege, Henne

AU - Maier, Andrea B

AU - Visser, Pieter Jelle

PY - 2020/9/1

Y1 - 2020/9/1

N2 - The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.

AB - The prevalence of brain pathologies increases with age and cognitive and physical function worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology, cognitive and physical function with age in 288 cognitively normal individuals aged 60-102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60-70 years old individuals. Prevalence of abnormal scores were estimated using generalized estimating equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology and cognitive and physical processes became abnormal with age.

KW - Biomarkers

KW - Brain aging

KW - Cognitive function

KW - Human aging

KW - ALZHEIMERS-DISEASE

KW - TEMPORAL RELATIONSHIP

KW - HANDGRIP STRENGTH

KW - MUSCLE STRENGTH

KW - APOE EPSILON-4

KW - OLDER-ADULTS

KW - SEX

KW - DEMENTIA

KW - PERFORMANCE

KW - PREVALENCE

U2 - 10.1093/gerona/glz180

DO - 10.1093/gerona/glz180

M3 - Article

C2 - 31411322

SN - 1079-5006

VL - 75

SP - 1609

EP - 1617

JO - Journals of Gerontology Series A-Biological Sciences and Medical Sciences

JF - Journals of Gerontology Series A-Biological Sciences and Medical Sciences

IS - 9

ER -

Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years

Abstract

Keywords

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