Associations of Ambulatory Blood Pressure With Urinary Caffeine and Caffeine Metabolite Excretions

Idris Guessous, Menno Pruijm, Belen Ponte, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Philippe Vuistiner, Jan Staessen, Yumei Gu, Fred Paccaud, Markus Mohaupt, Bruno Vogt, Antoinette Pechere-Berstchi, Pierre-Yves Martin, Michel Burnier, Chin B. Eap, Murielle Bochud*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Intake of caffeinated beverages might be associated with reduced cardiovascular mortality possibly via the lowering of blood pressure. We estimated the association of ambulatory blood pressure with urinary caffeine and caffeine metabolites in a population-based sample. Families were randomly selected from the general population of Swiss cities. Ambulatory blood pressure monitoring was conducted using validated devices. Urinary caffeine, paraxanthine, theophylline, and theobromine excretions were measured in 24 hours urine using ultrahigh performance liquid chromatography tandem mass spectrometry. We used mixed models to explore the associations of urinary excretions with blood pressure although adjusting for major confounders. The 836 participants (48.9% men) included in this analysis had mean age of 47.8 and mean 24-hour systolic and diastolic blood pressure of 120.1 and 78.0 mm Hg. For each doubling of caffeine excretion, 24-hour and night-time systolic blood pressure decreased by 0.642 and 1.107 mm Hg (both P values
Original languageEnglish
Pages (from-to)691-696
Issue number3
Publication statusPublished - Mar 2015


  • ambulatory blood pressure
  • caffeine
  • paraxanthine
  • population
  • theophylline


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