Associations between pretreatment physical performance tests and treatment complications in patients with non-small cell lung cancer: A systematic review

M.J.J. Voorn*, R.F.W. Franssen, J.M.W.F. Verlinden, G.P. Bootsma, D.K. de Ruysscher, B.C. Bongers, M.L.G. Janssen-Heijnen

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

This systematic review evaluated which outcome variables and cut-off values of pretreatment exercise tests are associated with treatment complications in patients with stage I-III non-small cell lung cancer (NSCLC). PRISMA and Cochrane guidelines were followed. A total of 38 studies with adult patients undergoing treatment for stage I-III NSCLC who completed pretreatment exercise tests, and of whom treatment-related complications were recorded were included. A lower oxygen uptake at peak exercise amongst several other variables on the cardiopulmonary exercise test and a lower performance on field tests, such as the incremental shuttle walk test, stair-climb test, and 6-minute walk test, were associated with a higher risk for postoperative complications and/ or postoperative mortality. Cut-off values were reported in a limited number of studies and were inconsistent. Due to the variety in outcomes, further research is needed to evaluate which outcomes and cut-off values of physical exercise tests are most clinically relevant.
Original languageEnglish
Number of pages13
JournalCritical Reviews in Oncology/Hematology
Volume158
DOIs
Publication statusPublished - 1 Feb 2021

Keywords

  • Aerobic capacity
  • Lung cancer
  • Perioperative care
  • Prehabilitation
  • Preoperative risk assessment
  • SURGERY
  • OXYGEN-CONSUMPTION
  • 6-MIN WALK
  • WALK TEST
  • HOSPITAL STAY
  • RESECTION
  • EXERCISE CAPACITY
  • OBSTRUCTIVE PULMONARY-DISEASE
  • POSTOPERATIVE COMPLICATIONS
  • INCREASED RISK

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