TY - JOUR
T1 - Associations between momentary mental states and concurrent social functioning after remission from first episode psychosis
T2 - A HAMLETT ecological momentary assessment study
AU - Djordjevic, Matej
AU - Jongsma, Hannah E.
AU - Simons, Claudia J.P.
AU - Oomen, Priscilla P.
AU - de Haan, Lieuwe
AU - Boonstra, Nynke
AU - Kikkert, Martijn
AU - Koops, Sanne
AU - Geraets, Chris N.W.
AU - Begemann, Marieke J.H.
AU - Marcelis, Machteld
AU - Veling, Wim
AU - HAMLETT-OPHELIA Consortium
N1 - Funding Information:
The HAMLETT-OPHELIA project is financed by grants from the Dutch Medical Science Foundation ZonMW, #848041003 and #636340001, to Principal Investigator Professor I.E. Sommer. ZonMW had no role in the study design, collection, management, analysis and interpretation of data, writing the report, or the decision to submit the report for publication. MD is funded by an internal research grant of the University Medical Center Groningen (MD-PhD grant number 21-40).The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Iris Sommer reports financial support was provided by Netherlands Organisation for Health Research and Development. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Funding Information:
The HAMLETT-OPHELIA project is financed by grants from the Dutch Medical Science Foundation ZonMW, #848041003 and #636340001, to Principal Investigator Professor I.E. Sommer. ZonMW had no role in the study design, collection, management, analysis and interpretation of data, writing the report, or the decision to submit the report for publication. MD is funded by an internal research grant of the University Medical Center Groningen (MD-PhD grant number 21-40).
Publisher Copyright:
© 2024 The Authors
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Background: Symptom severity and social functioning are important outcomes after first episode psychosis (FEP), yet current evidence about associations between them is inconsistent and lacks (subclinical) momentary insights. Methods: The current Ecological Momentary Assessment (EMA) study was conducted in 58 people in remission from FEP, as part of the HAMLETT (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment) trial. At baseline, participants were prompted to report momentary mental states and social context 10x/day for eight consecutive days, including psychotic experiences (PEs), motivation/drive and negative affect, that may indicate proxies of (subclinical) psychotic, negative and general affective symptoms, respectively. We employed multilevel mixed-effects regressions to investigate associations between self-reported mental states and concurrent activity or social company and subjective appraisal thereof. We also conducted retrospective clinical assessments of symptoms (PANSS) and social functioning (WHODAS 2.0) and investigated their cross-sectional associations using multivariable linear regression. Results: Analyses of 3101 EMA-questionnaires showed that lower motivation/drive was associated with more passive activity and less company (OR = 0.96 [95%CI: 0.96; 0.97], OR = 0.95 [95%CI: 0.93; 0.96], N.B. ORs per 1-point symptom-score change). PEs and negative affect were associated with more proactive activity (OR = 1.02 [95%CI: 1.00; 1.03], OR = 1.02 [95%CI: 1.01; 1.03]). All three mental state domains were associated with lower activity appraisal overall, though activity-specific associations differed. PEs and negative affect were associated with lower company appraisal (B = -0.25 [95%CI: -0.36; -0.14], B = -0.15 [95%CI: -0.23; -0.06]). When assessed retrospectively, only PANSS general psychopathology was associated with poorer social functioning (B = 2.52 [95%CI: 1.69; 3.34]). Conclusion: Self-reported PEs, momentary motivation/drive and general affective symptoms are associated with daily-life functioning after remission from FEP. Retrospective observer-rated and momentary self-report assessment methods do not measure the same aspects or intensity of psychopathology.
AB - Background: Symptom severity and social functioning are important outcomes after first episode psychosis (FEP), yet current evidence about associations between them is inconsistent and lacks (subclinical) momentary insights. Methods: The current Ecological Momentary Assessment (EMA) study was conducted in 58 people in remission from FEP, as part of the HAMLETT (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment) trial. At baseline, participants were prompted to report momentary mental states and social context 10x/day for eight consecutive days, including psychotic experiences (PEs), motivation/drive and negative affect, that may indicate proxies of (subclinical) psychotic, negative and general affective symptoms, respectively. We employed multilevel mixed-effects regressions to investigate associations between self-reported mental states and concurrent activity or social company and subjective appraisal thereof. We also conducted retrospective clinical assessments of symptoms (PANSS) and social functioning (WHODAS 2.0) and investigated their cross-sectional associations using multivariable linear regression. Results: Analyses of 3101 EMA-questionnaires showed that lower motivation/drive was associated with more passive activity and less company (OR = 0.96 [95%CI: 0.96; 0.97], OR = 0.95 [95%CI: 0.93; 0.96], N.B. ORs per 1-point symptom-score change). PEs and negative affect were associated with more proactive activity (OR = 1.02 [95%CI: 1.00; 1.03], OR = 1.02 [95%CI: 1.01; 1.03]). All three mental state domains were associated with lower activity appraisal overall, though activity-specific associations differed. PEs and negative affect were associated with lower company appraisal (B = -0.25 [95%CI: -0.36; -0.14], B = -0.15 [95%CI: -0.23; -0.06]). When assessed retrospectively, only PANSS general psychopathology was associated with poorer social functioning (B = 2.52 [95%CI: 1.69; 3.34]). Conclusion: Self-reported PEs, momentary motivation/drive and general affective symptoms are associated with daily-life functioning after remission from FEP. Retrospective observer-rated and momentary self-report assessment methods do not measure the same aspects or intensity of psychopathology.
KW - Early psychosis
KW - Ecological momentary assessment
KW - Experience sampling method
KW - First episode psychosis
KW - Schizophrenia spectrum disorders
KW - Social functioning
U2 - 10.1016/j.jpsychires.2024.12.002
DO - 10.1016/j.jpsychires.2024.12.002
M3 - Article
SN - 0022-3956
VL - 181
SP - 560
EP - 569
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -