Association of toll-like receptor 10 polymorphisms with paediatric idiopathic uveitis in Han Chinese

Meng Lv, Handan Tan, Jing Deng, Liping Du, Guannan Su, Qingfeng Wang, Zhenyu Zhong, Xiao Tan, Qingfeng Cao, Aize Kijlstra, Peizeng Yang*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Aims We aimed to determine whether paediatric idiopathic uveitis (PIU) and juvenile idiopathic arthritis associated paediatric uveitis (JIA-PU) have an association with Toll-like receptor 10 (TLR10) gene polymorphisms in Han Chinese.

Methods Ten tag single nucleotide polymorphisms (SNPs) of TLR10 were analysed in 992 PIU patients, 127 JIA-PU patients and 1600 controls using the Sequenom MassARRAY system and iPLEX Gold assay. Genotype and allele frequencies were analysed using the chi 2 test. A stratified analysis was performed according to the clinical features of PIU.

Results Increased frequencies of the rs2101521 A allele, rs10004195 A allele, rs11725309 CC genotype and rs6841698 AA genotype were found in PIU patients compared with controls (corrected p values (Pc)=1.81x10(-4), Pc=1.12x10(-2), Pc=2.41x10(-2) and Pc=3.29x10(-3), respectively). There was no association between these 10 tag SNPs and JIA-PU. In the stratified analysis, the frequency of the rs6841698 A allele was higher in PIU patients with cataract (Pc=1.45x10(-6)). The frequencies of the rs2101521 A allele and rs6841698 AA genotype were increased in PIU patients with band keratopathy (BK) (Pc=2.32x10(-2), Pc=3.30x10(-3), respectively).

Conclusion TLR10 gene polymorphisms (rs2101521, rs10004195, rs11725309 and rs6841698) confer susceptibility to PIU in Han Chinese. In a stratified analysis, rs2101521 and rs6841698 are associated with PIU with BK, and rs6841698 correlates with PIU with cataract.

Original languageEnglish
Pages (from-to)1467-1471
Number of pages5
JournalBritish Journal of Ophthalmology
Volume104
Issue number10
Early online date4 Jul 2019
DOIs
Publication statusPublished - Oct 2020

Keywords

  • JUVENILE RHEUMATOID-ARTHRITIS
  • TERTIARY REFERRAL CENTER
  • CLINICAL-FEATURES
  • GENETIC-VARIATION
  • HUMAN TLR10
  • SUSCEPTIBILITY
  • DISEASE
  • IRIDOCYCLITIS
  • CELLS

Cite this