TY - JOUR
T1 - Association of the Amount and Pattern of Physical Activity With Arterial Stiffness
T2 - The Maastricht Study
AU - Vandercappellen, Evelien J.
AU - Henry, Ronald M. A.
AU - Savelberg, Hans H. C. M.
AU - van der Berg, Julianne D.
AU - Reesink, Koen D.
AU - Schaper, Nicolaas C.
AU - Eussen, Simone J. P. M.
AU - van Dongen, Martien C. J. M.
AU - Dagnelie, Pieter C.
AU - Schram, Miranda T.
AU - van Greevenbroek, Marleen M. J.
AU - Wesselius, Anke
AU - van der Kallen, Carla J. H.
AU - Kohler, Sebastian
AU - Stehouwer, Coen D. A.
AU - Koster, Annemarie
N1 - Funding Information:
This study was supported by the European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC; Maastricht), CARIM School for Cardiovascular Diseases (Maastricht), CAPHRI Care and Public Health Research Institute (Maastricht), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht), Stichting Annadal (Maastricht), and the Health Foundation Limburg (Maastricht), and by unrestricted grants from Janssen-Cilag B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands). This project was partly funded through a European Foundation for the Study of Diabetes award supported by AstraZeneca.
Publisher Copyright:
© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2020/10/20
Y1 - 2020/10/20
N2 - Background Arterial stiffness is an independent risk factor for cardiovascular disease and can be beneficially influenced by physical activity. However, it is not clear how an individual's physical activity pattern over a week is associated with arterial stiffness. Therefore, we examined the associations of the amount and pattern of higher intensity physical activity with arterial stiffness. Methods and Results Data from the Maastricht Study (n=1699; mean age: 60 +/- 8 years, 49.4% women, 26.9% type 2 diabetes mellitus) were used. Arterial stiffness was assessed by carotid-to-femoral pulse wave velocity and carotid distensibility. The amount (continuous variable as h/wk) and pattern (categorical variable) of higher intensity physical activity were assessed with the activPAL3. Activity groups were: inactive (150 min/wk in 150 min/wk in >= 3 sessions). In the fully adjusted model (adjusted for demographic, lifestyle, and cardiovascular risk factors), higher intensity physical activity was associated with lower carotid-to-femoral pulse wave velocity (amount: beta = -0.05, 95% CI, -0.09 to -0.01; insufficiently active: beta = -0.33, 95% CI, -0.55 to -0.11; weekend warrior: beta = -0.38, 95% CI, -0.64 to -0.12; and regularly active: beta = -0.46, 95% CI, -0.71 to -0.21 [reference: inactive]). These associations were stronger in those with type 2 diabetes mellitus. There was no statistically significant association between higher intensity physical activity with carotid distensibility. Conclusions Participating in higher intensity physical activity was associated with lower carotid-to-femoral pulse wave velocity, but there was no difference between the regularly actives and the weekend warriors. From the perspective of arterial stiffness, engaging higher intensity physical activity, regardless of the weekly pattern, may be an important strategy to reduce the risk of cardiovascular disease, particularly in individuals with type 2 diabetes mellitus.
AB - Background Arterial stiffness is an independent risk factor for cardiovascular disease and can be beneficially influenced by physical activity. However, it is not clear how an individual's physical activity pattern over a week is associated with arterial stiffness. Therefore, we examined the associations of the amount and pattern of higher intensity physical activity with arterial stiffness. Methods and Results Data from the Maastricht Study (n=1699; mean age: 60 +/- 8 years, 49.4% women, 26.9% type 2 diabetes mellitus) were used. Arterial stiffness was assessed by carotid-to-femoral pulse wave velocity and carotid distensibility. The amount (continuous variable as h/wk) and pattern (categorical variable) of higher intensity physical activity were assessed with the activPAL3. Activity groups were: inactive (150 min/wk in 150 min/wk in >= 3 sessions). In the fully adjusted model (adjusted for demographic, lifestyle, and cardiovascular risk factors), higher intensity physical activity was associated with lower carotid-to-femoral pulse wave velocity (amount: beta = -0.05, 95% CI, -0.09 to -0.01; insufficiently active: beta = -0.33, 95% CI, -0.55 to -0.11; weekend warrior: beta = -0.38, 95% CI, -0.64 to -0.12; and regularly active: beta = -0.46, 95% CI, -0.71 to -0.21 [reference: inactive]). These associations were stronger in those with type 2 diabetes mellitus. There was no statistically significant association between higher intensity physical activity with carotid distensibility. Conclusions Participating in higher intensity physical activity was associated with lower carotid-to-femoral pulse wave velocity, but there was no difference between the regularly actives and the weekend warriors. From the perspective of arterial stiffness, engaging higher intensity physical activity, regardless of the weekly pattern, may be an important strategy to reduce the risk of cardiovascular disease, particularly in individuals with type 2 diabetes mellitus.
KW - accelerometry
KW - arterial stiffness
KW - cardiovascular disease
KW - physical activity
KW - type 2 diabetes mellitus
U2 - 10.1161/JAHA.120.017502
DO - 10.1161/JAHA.120.017502
M3 - Article
C2 - 33054610
SN - 2047-9980
VL - 9
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 20
M1 - 017502
ER -