Association of serum uric acid levels to inflammation biomarkers and endothelial dysfunction in obese prepubertal children

Miguel Valle*, Rosario Martos, María Dolores Cañete, Rosario Valle, Eva L van Donkelaar, Francisco Bermudo, Ramón Cañete

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: High serum uric acid (SUA) levels are present in patients with metabolic syndrome (MetS), when the latter is associated with endothelial dysfunction, inflammation, and hypertension. This increase in SUA levels may have a key role in cardiovascular diseases.

OBJECTIVE: We aim to quantify the differences in inflammation biomarkers, endothelial dysfunction, and parameters associated with MetS in obese prepubertal children compared to non-obese children, and determine if there is a relationship between uric acid levels and these variables.

METHODS: A cross-sectional study was carried out on obese children (6-9 yr old). The study included 43 obese children and the same number of non-obese children (control group), matched by age and sex. SUA, C-reactive protein (CRP), interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), glucose, insulin, lipid profile, and blood pressure were all measured.

RESULTS: SUA levels, CRP, and sICAM-1 were significantly higher in obese children. In the obese group, SUA levels showed a positive correlation with body mass index (BMI), insulin, homeostasis model assessment for insulin resistance (HOMA-IR), CRP, IL-6, sICAM-1, and triglycerides (TGs), and correlated negatively with high-density lipoprotein cholesterol (HDL-C) and Apo-AI, but not with Apo-B. When adjusted for age, sex, and creatinine, it was noted that SUA levels are independent predictive factors for sICAM-1, CRP, and IL-6.

CONCLUSIONS: Inflammation biomarkers, endothelial dysfunction, and parameters associated with MetS are elevated in obese prepubertal children and correlate to uric acid levels.

Original languageEnglish
Pages (from-to)441-7
Number of pages7
JournalPediatric Diabetes
Issue number6
Publication statusPublished - Sep 2015


  • Biomarkers
  • Body Mass Index
  • C-Reactive Protein
  • Child
  • Cross-Sectional Studies
  • Endothelium, Vascular
  • Female
  • Humans
  • Hyperuricemia
  • Inflammation Mediators
  • Intercellular Adhesion Molecule-1
  • Male
  • Metabolic Syndrome X
  • Pediatric Obesity
  • Risk Factors
  • Solubility
  • Spain
  • Up-Regulation
  • Uric Acid
  • Vasculitis

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