Abstract
We aimed to investigate the association between Red Blood Cell Distribution Width (RDW) and Neutrophil-to-Lymphocyte Ratio (NLR), simple, rapidly assessed markers from the complete blood count with vascular calcification (VC)/stiffness and cardiovascular disease (CVD) in chronic kidney disease (CKD). Dephosphorylated, uncarboxylated matrix Gla-protein (dp-ucMGP), and central/peripheral hemodynamics' parameters were measured in 158 CKD patients, including Hemodialysis and Peritoneal Dialysis. Spearman's rho analysis showed that RDW correlated with C-reactive protein (CRP) (r = 0.29, p < 0.001), dp-ucMGP (r = 0.43, p = < 0.0001), central diastolic blood pressure (DBP) (r = -0.19, p = 0.02), and albuminuria (r = -0.17, p = 0.03). NLR correlated with the duration of CVD (r = 0.32, p < 0.001), CRP (r = 0.27, p = 0.01), dp-ucMGP (r = 0.43, p < 0.0001), central DBP (r = -0.32, p < 0.0001) and eGFR (r = -0.25, p = 0.04). In multiple regression models, circulating dp-ucMGP was an independent predictor of RDW (beta = 0.001, p = 0.001) and NLR (beta = 0.002, p = 0.002). In CKD patients, RDW and NLR are associated with traditional and novel markers of VC and CVD.
Original language | English |
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Article number | 303 |
Number of pages | 15 |
Journal | Metabolites |
Volume | 13 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Feb 2023 |
Keywords
- cardiovascular disease
- chronic kidney disease
- dephosphorylatyed uncarboxylated Matrix Gla Protein
- endothelial dysfunction
- inflammation
- red blood cell distribution width
- Neutrophil-to-lymphocyte ratio
- vascular calcification
- CORONARY-ARTERY CALCIFICATION
- PREDICTING ALL-CAUSE
- VASCULAR CALCIFICATION
- PROGNOSTIC MARKER
- CAUSE MORTALITY
- HEART-FAILURE
- INFLAMMATION
- BIOMARKERS
- PARAMETERS
- RISK