TY - JOUR
T1 - Association of Recognized and Unrecognized Myocardial Infarction With Depressive and Anxiety Disorders in 125,988 Individuals
T2 - A Report of the Lifelines Cohort Study
AU - Iozzia, Giulia
AU - de Miranda Azevedo, Ricardo
AU - van der Harst, Pim
AU - Rosmalen, Judith G. M.
AU - de Jonge, Peter
AU - Roest, Annelieke M.
N1 - Funding Information:
Source of Funding and Conflicts of Interest: The Lifelines Biobank initiative has been made possible by subsidy from the Dutch Ministry of Health, Welfare and Sport; the Dutch Ministry of Economic Affairs, the University Medical Center Groningen (UMCG the Netherlands), University Groningen, and the Northern Provinces of the Netherlands. The authors report no conflict of interest.
Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2020/10
Y1 - 2020/10
N2 - Objective No previous study has focused on recognition of myocardial infarction (MI) and the presence of both depressive and anxiety disorders in a large population-based sample. The aim of this study was to investigate the association of recognized MI (RMI) and unrecognized MI (UMI) with depressive and anxiety disorders. Methods Analyses included 125,988 individuals enrolled in the Lifelines study. Current mental disorders according to theDiagnostic and Statistical Manual of Mental Disorders(Fourth Edition) were assessed with the Mini-International Neuropsychiatric Interview. UMI was detected using electrocardiogram in participants who did not report a history of MI. The classification of RMI was based on self-reported MI history together with the use of either antithrombotic medications or electrocardiogram signs of MI. Analyses were adjusted for age, sex, smoking, somatic comorbidities, and physical health-related quality of life as measured by the RAND 36-Item Health Survey in different models. Results Participants with RMI had significantly higher odds of having any depressive and any anxiety disorder as compared with participants without MI (depressive disorder: odds ratio [OR] = 1.86, 95% confidence interval [CI] = 1.38-2.52; anxiety disorder: OR = 1.60, 95% CI = 1.32-1.94) after adjustment for age and sex. Participants with UMI did not differ from participants without MI (depressive disorder: OR = 1.60, 95% CI = 0.96-2.64; anxiety disorder: OR = 0.73, 95% CI = 0.48-1.11). After additional adjustment for somatic comorbidities and low physical health-related quality of life, the association between RMI with any depressive disorder was no longer statistically significant (OR = 1.18; 95% CI =0.84-1.65), but the association with any anxiety disorder remained (OR = 1.27, 95% CI = 1.03-1.57). Conclusions Recognition of MI seems to play a major role in the occurrence of anxiety, but not depressive, disorders.
AB - Objective No previous study has focused on recognition of myocardial infarction (MI) and the presence of both depressive and anxiety disorders in a large population-based sample. The aim of this study was to investigate the association of recognized MI (RMI) and unrecognized MI (UMI) with depressive and anxiety disorders. Methods Analyses included 125,988 individuals enrolled in the Lifelines study. Current mental disorders according to theDiagnostic and Statistical Manual of Mental Disorders(Fourth Edition) were assessed with the Mini-International Neuropsychiatric Interview. UMI was detected using electrocardiogram in participants who did not report a history of MI. The classification of RMI was based on self-reported MI history together with the use of either antithrombotic medications or electrocardiogram signs of MI. Analyses were adjusted for age, sex, smoking, somatic comorbidities, and physical health-related quality of life as measured by the RAND 36-Item Health Survey in different models. Results Participants with RMI had significantly higher odds of having any depressive and any anxiety disorder as compared with participants without MI (depressive disorder: odds ratio [OR] = 1.86, 95% confidence interval [CI] = 1.38-2.52; anxiety disorder: OR = 1.60, 95% CI = 1.32-1.94) after adjustment for age and sex. Participants with UMI did not differ from participants without MI (depressive disorder: OR = 1.60, 95% CI = 0.96-2.64; anxiety disorder: OR = 0.73, 95% CI = 0.48-1.11). After additional adjustment for somatic comorbidities and low physical health-related quality of life, the association between RMI with any depressive disorder was no longer statistically significant (OR = 1.18; 95% CI =0.84-1.65), but the association with any anxiety disorder remained (OR = 1.27, 95% CI = 1.03-1.57). Conclusions Recognition of MI seems to play a major role in the occurrence of anxiety, but not depressive, disorders.
KW - myocardial infarction
KW - depression
KW - anxiety
KW - epidemiology
KW - AG= agoraphobia
KW - CHD= coronary heart disease
KW - DSM= Diagnostic and Statistical Manual of Mental Disorders
KW - ECG= electrocardiogram
KW - HRQOL= health-related quality of life
KW - MDD= major depressive disorder
KW - MCS= mental component summary
KW - MINI= Mini-International Neuropsychiatric Interview
KW - MI= myocardial infarction
KW - OR= odds ratio
KW - PCS= physical component summary
KW - PD= panic disorder
KW - RMI= recognized myocardial infarction
KW - SD= standard deviation
KW - UMI= unrecognized myocardial infarction
KW - CORONARY-HEART-DISEASE
KW - PROGNOSTIC ASSOCIATION
KW - CARDIOVASCULAR-DISEASE
KW - UNIVERSAL DEFINITION
KW - ANXIOUS HEART
KW - PREVALENCE
KW - MORTALITY
KW - RISK
KW - METAANALYSIS
KW - EVENTS
U2 - 10.1097/psy.0000000000000846
DO - 10.1097/psy.0000000000000846
M3 - Article
C2 - 32732499
SN - 0033-3174
VL - 82
SP - 736
EP - 743
JO - Psychosomatic Medicine
JF - Psychosomatic Medicine
IS - 8
ER -